| 1 | Sat 31 Aug | 183-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-3 RB Leipzig |
| 2 | Sat 14 Sep | 180-0 v 1 FC Union BerlinRB Leipzig 0-0 1 FC Union Berlin |
| 3 | Sun 22 Sep | 180-0 v FC St PauliFC St Pauli 0-0 RB Leipzig |
| 4 | Sat 28 Sep | 184-0 v FC AugsburgRB Leipzig 4-0 FC Augsburg |
| 5 | Sun 6 Oct | 181-0 v 1 FC Heidenheim1 FC Heidenheim 0-1 RB Leipzig |
| 6 | Sat 19 Oct | 18 2-0 v Mainz 05Mainz 05 0-2 RB Leipzig |
| 7 | Sat 26 Oct | 18 3-1 v SC FreiburgRB Leipzig 3-1 SC Freiburg |
| 8 | Sat 2 Nov | 181-2 v Borussia DortmundBorussia Dortmund 2-1 RB Leipzig |
| 9 | Sat 9 Nov | 18 0-0 v Borussia MönchengladbachRB Leipzig 0-0 Borussia Mönchengladbach |
| 10 | Sat 23 Nov | 183-4 v 1899 Hoffenheim1899 Hoffenheim 4-3 RB Leipzig |
| 11 | Sat 30 Nov | 18 1-5 v VfL WolfsburgRB Leipzig 1-5 VfL Wolfsburg |
| 12 | Sat 7 Dec | 18 2-0 v Holstein KielHolstein Kiel 0-2 RB Leipzig |
| 13 | Fri 20 Dec | 181-5 v Bayern MunichBayern Munich 5-1 RB Leipzig |
| 14 | Sun 12 Jan | 184-2 v Werder BremenRB Leipzig 4-2 Werder Bremen |
| 15 | Wed 15 Jan | 181-2 v VfB StuttgartVfB Stuttgart 2-1 RB Leipzig |
| 16 | Sat 18 Jan | 183-3 v VfL BochumVfL Bochum 3-3 RB Leipzig |
| 17 | Sat 25 Jan | 182-2 v Bayer 04 LeverkusenRB Leipzig 2-2 Bayer 04 Leverkusen |
| 18 | Fri 14 Feb | 180-0 v FC AugsburgFC Augsburg 0-0 RB Leipzig |
| 19 | Sun 23 Feb | 182-2 v 1 FC HeidenheimRB Leipzig 2-2 1 FC Heidenheim |
| 20 | Sat 1 Mar | 181-2 v Mainz 05RB Leipzig 1-2 Mainz 05 |
| 21 | Sat 8 Mar | 180-0 v SC FreiburgSC Freiburg 0-0 RB Leipzig |
| 22 | Sat 5 Apr | 183-1 v 1899 HoffenheimRB Leipzig 3-1 1899 Hoffenheim |
| 23 | Fri 11 Apr | 183-2 v VfL WolfsburgVfL Wolfsburg 2-3 RB Leipzig |
| 24 | Sat 19 Apr | 181-1 v Holstein KielRB Leipzig 1-1 Holstein Kiel |
| 25 | Sat 26 Apr | 180-4 v Eintracht FrankfurtEintracht Frankfurt 4-0 RB Leipzig |
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