| 1 | Thu 5 Aug 2021 | 4 1-1 v St JohnstoneGalatasaray 1-1 St Johnstone | UEFA Europa League First Qualifying Round |
| 2 | Thu 12 Aug 2021 | 44-2 v St JohnstoneSt Johnstone 2-4 Galatasaray | UEFA Europa League First Qualifying Round |
| 3 | Mon 16 Aug 2021 | 4 2-0 v GiresunsporGiresunspor 0-2 Galatasaray | Turkish Süper Lig |
| 4 | Thu 19 Aug 2021 | 41-1 v Randers FCRanders FC 1-1 Galatasaray | UEFA Europa League Qualifying Play-off Round |
| 5 | Mon 23 Aug 2021 | 42-1 v HataysporGalatasaray 2-1 Hatayspor | Turkish Süper Lig |
| 6 | Thu 26 Aug 2021 | 42-1 v Randers FCGalatasaray 2-1 Randers FC | UEFA Europa League Qualifying Play-off Round |
| 7 | Sun 29 Aug 2021 | 42-2 v Kasımpaşa SKKasımpaşa SK 2-2 Galatasaray | Turkish Süper Lig |
| 8 | Sun 12 Sep 2021 | 42-2 v TrabzonsporTrabzonspor 2-2 Galatasaray | Turkish Süper Lig |
| 9 | Thu 16 Sep 2021 | 41-0 v LazioGalatasaray 1-0 Lazio | UEFA Europa League Group E |
| 10 | Sun 19 Sep 2021 | 40-1 v AlanyasporGalatasaray 0-1 Alanyaspor | Turkish Süper Lig |
| 11 | Wed 22 Sep 2021 | 40-3 v KayserisporKayserispor 3-0 Galatasaray | Turkish Süper Lig |
| 12 | Thu 30 Sep 2021 | 40-0 v MarseilleMarseille 0-0 Galatasaray | UEFA Europa League Group E |
| 13 | Sun 3 Oct 2021 | 43-2 v Çaykur RizesporÇaykur Rizespor 2-3 Galatasaray | Turkish Süper Lig |
| 14 | Sun 17 Oct 2021 | 4 1-0 v KonyasporGalatasaray 1-0 Konyaspor | Turkish Süper Lig |
| 15 | Thu 21 Oct 2021 | 4 1-0 v Lokomotiv MoscowLokomotiv Moscow 0-1 Galatasaray | UEFA Europa League Group E |
| 16 | Mon 25 Oct 2021 | 4 1-2 v BeşiktaşBeşiktaş 2-1 Galatasaray | Turkish Süper Lig |
| 17 | Sun 31 Oct 2021 | 42-0 v Gazişehir GaziantepGalatasaray 2-0 Gazişehir Gaziantep | Turkish Süper Lig |
| 18 | Sun 21 Nov 2021 | 41-2 v FenerbahçeGalatasaray 1-2 Fenerbahçe | Turkish Süper Lig |
| 19 | Thu 25 Nov 2021 | 44-2 v MarseilleGalatasaray 4-2 Marseille | UEFA Europa League Group E |
| 20 | Sun 28 Nov 2021 | 40-0 v Yeni MalatyasporYeni Malatyaspor 0-0 Galatasaray | Turkish Süper Lig |
| 21 | Sat 4 Dec 2021 | 42-2 v AltayGalatasaray 2-2 Altay | Turkish Süper Lig |
| 22 | Thu 9 Dec 2021 | 40-0 v LazioLazio 0-0 Galatasaray | UEFA Europa League Group E |
| 23 | Mon 13 Dec 2021 | 40-1 v SivassporSivasspor 1-0 Galatasaray | Turkish Süper Lig |
| 24 | Tue 21 Dec 2021 | 4 0-2 v Adana DemirsporAdana Demirspor 2-0 Galatasaray | Turkish Süper Lig |
| 25 | Sun 16 Jan 2022 | 4 2-4 v HataysporHatayspor 4-2 Galatasaray | Turkish Süper Lig |
| 26 | Sun 23 Jan 2022 | 41-2 v TrabzonsporGalatasaray 1-2 Trabzonspor | Turkish Süper Lig |
| 27 | Sun 6 Feb 2022 | 41-1 v AlanyasporAlanyaspor 1-1 Galatasaray | Turkish Süper Lig |
| 28 | Sat 12 Feb 2022 | 41-1 v KayserisporGalatasaray 1-1 Kayserispor | Turkish Süper Lig |
| 29 | Mon 21 Feb 2022 | 43-2 v Göztepe SKGöztepe SK 2-3 Galatasaray | Turkish Süper Lig |
| 30 | Sun 27 Feb 2022 | 4 4-2 v Çaykur RizesporGalatasaray 4-2 Çaykur Rizespor | Turkish Süper Lig |
| 31 | Sat 5 Mar 2022 | 40-2 v KonyasporKonyaspor 2-0 Galatasaray | Turkish Süper Lig |
| 32 | Thu 10 Mar 2022 | 4 0-0 v BarcelonaBarcelona 0-0 Galatasaray | UEFA Europa League Round of 16 |
| 33 | Mon 14 Mar 2022 | 42-1 v BeşiktaşGalatasaray 2-1 Beşiktaş | Turkish Süper Lig |
| 34 | Thu 17 Mar 2022 | 41-2 v BarcelonaGalatasaray 1-2 Barcelona | UEFA Europa League Round of 16 |
| 35 | Sun 20 Mar 2022 | 41-3 v Gazişehir GaziantepGazişehir Gaziantep 3-1 Galatasaray | Turkish Süper Lig |
| 36 | Sat 2 Apr 2022 | 42-0 v Fatih KaragümrükGalatasaray 2-0 Fatih Karagümrük | Turkish Süper Lig |
| 37 | Sun 10 Apr 2022 | 4 0-2 v FenerbahçeFenerbahçe 2-0 Galatasaray | Turkish Süper Lig |
| 38 | Mon 18 Apr 2022 | 42-0 v Yeni MalatyasporGalatasaray 2-0 Yeni Malatyaspor | Turkish Süper Lig |
| 39 | Sun 1 May 2022 | 42-3 v SivassporGalatasaray 2-3 Sivasspor | Turkish Süper Lig |
| 40 | Sat 7 May 2022 | 40-0 v İstanbul Başakşehirİstanbul Başakşehir 0-0 Galatasaray | Turkish Süper Lig |
| 41 | Fri 20 May 2022 | 41-1 v AntalyasporAntalyaspor 1-1 Galatasaray | Turkish Süper Lig |
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