| 1 | Sat 14 Aug 2021 | 352-1 v FC TwenteFortuna Sittard 2-1 FC Twente | Dutch Eredivisie |
| 2 | Sun 12 Sep 2021 | 351-3 v Sparta RotterdamSparta Rotterdam 3-1 Fortuna Sittard | Dutch Eredivisie |
| 3 | Sat 18 Sep 2021 | 350-1 v sc Heerenveensc Heerenveen 1-0 Fortuna Sittard | Dutch Eredivisie |
| 4 | Tue 21 Sep 2021 | 350-5 v AjaxFortuna Sittard 0-5 Ajax | Dutch Eredivisie |
| 5 | Sat 25 Sep 2021 | 351-1 v VitesseVitesse 1-1 Fortuna Sittard | Dutch Eredivisie |
| 6 | Sat 2 Oct 2021 | 351-3 v NEC NijmegenFortuna Sittard 1-3 NEC Nijmegen | Dutch Eredivisie |
| 7 | Fri 22 Oct 2021 | 351-1 v Willem IIWillem II 1-1 Fortuna Sittard | Dutch Eredivisie |
| 8 | Sun 7 Nov 2021 | 351-4 v PSV EindhovenFortuna Sittard 1-4 PSV Eindhoven | Dutch Eredivisie |
| 9 | Sat 20 Nov 2021 | 351-3 v Heracles AlmeloHeracles Almelo 3-1 Fortuna Sittard | Dutch Eredivisie |
| 10 | Sat 27 Nov 2021 | 351-4 v FC GroningenFortuna Sittard 1-4 FC Groningen | Dutch Eredivisie |
| 11 | Thu 2 Dec 2021 | 351-2 v AZ AlkmaarAZ Alkmaar 2-1 Fortuna Sittard | Dutch Eredivisie |
| 12 | Sun 5 Dec 2021 | 35 0-5 v FeyenoordFeyenoord 5-0 Fortuna Sittard | Dutch Eredivisie |
| 13 | Sat 11 Dec 2021 | 351-0 v PEC ZwollePEC Zwolle 0-1 Fortuna Sittard | Dutch Eredivisie |
| 14 | Sat 18 Dec 2021 | 35 2-2 v FC UtrechtFortuna Sittard 2-2 FC Utrecht | Dutch Eredivisie |
| 15 | Wed 22 Dec 2021 | 350-5 v AjaxAjax 5-0 Fortuna Sittard | Dutch Eredivisie |
| 16 | Sun 16 Jan 2022 | 351-2 v AZ AlkmaarFortuna Sittard 1-2 AZ Alkmaar | Dutch Eredivisie |
| 17 | Sun 23 Jan 2022 | 351-2 v RKC WaalwijkRKC Waalwijk 2-1 Fortuna Sittard | Dutch Eredivisie |
| 18 | Sat 5 Feb 2022 | 352-0 v sc HeerenveenFortuna Sittard 2-0 sc Heerenveen | Dutch Eredivisie |
| 19 | Sun 6 Mar 2022 | 350-1 v PEC ZwolleFortuna Sittard 0-1 PEC Zwolle | Dutch Eredivisie |
| 20 | Sun 13 Mar 2022 | 35 1-0 v Willem IIFortuna Sittard 1-0 Willem II | Dutch Eredivisie |
| 21 | Sun 3 Apr 2022 | 35 0-2 v Heracles AlmeloFortuna Sittard 0-2 Heracles Almelo | Dutch Eredivisie |
| 22 | Sat 9 Apr 2022 | 351-1 v FC UtrechtFC Utrecht 1-1 Fortuna Sittard | Dutch Eredivisie |
| 23 | Sat 7 May 2022 | 35 2-1 v FC TwenteFC Twente 1-2 Fortuna Sittard | Dutch Eredivisie |
| 24 | Wed 11 May 2022 | 351-2 v VitesseFortuna Sittard 1-2 Vitesse | Dutch Eredivisie |
| 25 | Sun 15 May 2022 | 351-0 v NEC NijmegenNEC Nijmegen 0-1 Fortuna Sittard | Dutch Eredivisie |
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