| 1 | Tue 2 Aug 2022 | 82-2 v MacclesfieldMacclesfield 2-2 FC United of Manchester | Friendly |
| 2 | Sat 13 Aug 2022 | 101-2 v Atherton CollieriesFC United of Manchester 1-2 Atherton Collieries | Northern Premier League - Premier Division |
| 3 | Tue 16 Aug 2022 | 74-1 v Belper TownBelper Town 1-4 FC United of Manchester | Northern Premier League - Premier Division |
| 4 | Sat 20 Aug 2022 | 7 2-0 v Whitby TownWhitby Town 0-2 FC United of Manchester | Northern Premier League - Premier Division |
| 5 | Sat 3 Sep 2022 | 71-0 v Witton AlbionWitton Albion 0-1 FC United of Manchester | Emirates FA Cup First Qualifying Round |
| 6 | Sat 24 Sep 2022 | 111-0 v Warrington TownWarrington Town 0-1 FC United of Manchester | Northern Premier League - Premier Division |
| 7 | Tue 27 Sep 2022 | 104-0 v LiversedgeLiversedge 0-4 FC United of Manchester | Northern Premier League - Premier Division |
| 8 | Sat 1 Oct 2022 | 101-1 v MarineFC United of Manchester 1-1 Marine | Northern Premier League - Premier Division |
| 9 | Tue 4 Oct 2022 | 10 2-1 v South ShieldsFC United of Manchester 2-1 South Shields | Northern Premier League - Premier Division |
| 10 | Sat 8 Oct 2022 | 80-1 v LiversedgeFC United of Manchester 0-1 Liversedge | Isuzu FA Trophy Third Qualifying Round |
| 11 | Sat 12 Nov 2022 | 122-2 v Warrington RylandsFC United of Manchester 2-2 Warrington Rylands | Northern Premier League - Premier Division |
| 12 | Tue 15 Nov 2022 | 84-1 v KSV BeverenFC United of Manchester 4-1 KSV Beveren | Friendly |
| 13 | Sat 19 Nov 2022 | 81-3 v Gainsborough TrinityFC United of Manchester 1-3 Gainsborough Trinity | Northern Premier League - Premier Division |
| 14 | Sat 26 Nov 2022 | 110-1 v Stafford RangersStafford Rangers 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 15 | Sat 3 Dec 2022 | 72-0 v Belper TownFC United of Manchester 2-0 Belper Town | Northern Premier League - Premier Division |
| 16 | Mon 26 Dec 2022 | 44-0 v Ashton UnitedFC United of Manchester 4-0 Ashton United | Northern Premier League - Premier Division |
| 17 | Mon 2 Jan 2023 | 40-1 v RadcliffeRadcliffe 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 18 | Sat 4 Feb 2023 | 70-1 v Matlock TownMatlock Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 19 | Tue 7 Feb 2023 | 81-0 v GuiseleyFC United of Manchester 1-0 Guiseley | Northern Premier League - Premier Division |
| 20 | Sat 11 Feb 2023 | 70-2 v Lancaster CityLancaster City 2-0 FC United of Manchester | Northern Premier League - Premier Division |
| 21 | Sat 18 Feb 2023 | 71-1 v Stalybridge CelticFC United of Manchester 1-1 Stalybridge Celtic | Northern Premier League - Premier Division |
| 22 | Sat 25 Feb 2023 | 80-0 v Warrington RylandsWarrington Rylands 0-0 FC United of Manchester | Northern Premier League - Premier Division |
| 23 | Sat 4 Mar 2023 | 82-3 v LiversedgeFC United of Manchester 2-3 Liversedge | Northern Premier League - Premier Division |
| 24 | Sat 8 Apr 2023 | 12 5-2 v Bamber BridgeFC United of Manchester 5-2 Bamber Bridge | Northern Premier League - Premier Division |
| 25 | Mon 10 Apr 2023 | 85-0 v Ashton UnitedAshton United 0-5 FC United of Manchester | Northern Premier League - Premier Division |
| 26 | Sat 15 Apr 2023 | 80-1 v Stafford RangersFC United of Manchester 0-1 Stafford Rangers | Northern Premier League - Premier Division |
| 27 | Sat 22 Apr 2023 | 4 2-1 v Gainsborough TrinityGainsborough Trinity 1-2 FC United of Manchester | Northern Premier League - Premier Division |
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