| 1 | Tue 2 Aug 2022 | 32-2 v MacclesfieldMacclesfield 2-2 FC United of Manchester | Friendly |
| 2 | Sat 13 Aug 2022 | 121-2 v Atherton CollieriesFC United of Manchester 1-2 Atherton Collieries | Northern Premier League - Premier Division |
| 3 | Tue 16 Aug 2022 | 34-1 v Belper TownBelper Town 1-4 FC United of Manchester | Northern Premier League - Premier Division |
| 4 | Sat 20 Aug 2022 | 32-0 v Whitby TownWhitby Town 0-2 FC United of Manchester | Northern Premier League - Premier Division |
| 5 | Tue 23 Aug 2022 | 30-0 v Nantwich TownFC United of Manchester 0-0 Nantwich Town | Northern Premier League - Premier Division |
| 6 | Sat 27 Aug 2022 | 31-2 v Bamber BridgeBamber Bridge 2-1 FC United of Manchester | Northern Premier League - Premier Division |
| 7 | Mon 29 Aug 2022 | 141-2 v RadcliffeFC United of Manchester 1-2 Radcliffe | Northern Premier League - Premier Division |
| 8 | Sat 3 Sep 2022 | 3 1-0 v Witton AlbionWitton Albion 0-1 FC United of Manchester | Emirates FA Cup First Qualifying Round |
| 9 | Tue 6 Sep 2022 | 30-1 v Hyde UnitedHyde United 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 10 | Tue 13 Sep 2022 | 32-1 v Matlock TownFC United of Manchester 2-1 Matlock Town | Northern Premier League - Premier Division |
| 11 | Sat 17 Sep 2022 | 32-3 v Curzon AshtonFC United of Manchester 2-3 Curzon Ashton | Emirates FA Cup Second Qualifying Round |
| 12 | Tue 11 Oct 2022 | 144-2 v Morpeth TownFC United of Manchester 4-2 Morpeth Town | Northern Premier League - Premier Division |
| 13 | Tue 18 Oct 2022 | 161-2 v GuiseleyGuiseley 2-1 FC United of Manchester | Northern Premier League - Premier Division |
| 14 | Sat 29 Oct 2022 | 34-1 v Stalybridge CelticFC United of Manchester 4-1 Stalybridge Celtic | Manchester Premier Cup First Round |
| 15 | Tue 15 Nov 2022 | 34-1 v KSV BeverenFC United of Manchester 4-1 KSV Beveren | Friendly |
| 16 | Sat 28 Jan 2023 | 121-1 v Warrington TownFC United of Manchester 1-1 Warrington Town | Northern Premier League - Premier Division |
| 17 | Sat 4 Feb 2023 | 150-1 v Matlock TownMatlock Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 18 | Tue 7 Feb 2023 | 31-0 v GuiseleyFC United of Manchester 1-0 Guiseley | Northern Premier League - Premier Division |
| 19 | Sat 11 Feb 2023 | 30-2 v Lancaster CityLancaster City 2-0 FC United of Manchester | Northern Premier League - Premier Division |
| 20 | Sat 18 Feb 2023 | 151-1 v Stalybridge CelticFC United of Manchester 1-1 Stalybridge Celtic | Northern Premier League - Premier Division |
| 21 | Sat 25 Feb 2023 | 30-0 v Warrington RylandsWarrington Rylands 0-0 FC United of Manchester | Northern Premier League - Premier Division |
| 22 | Sat 4 Mar 2023 | 32-3 v LiversedgeFC United of Manchester 2-3 Liversedge | Northern Premier League - Premier Division |
| 23 | Sat 11 Mar 2023 | 30-1 v Atherton CollieriesAtherton Collieries 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 24 | Tue 14 Mar 2023 | 32-1 v South ShieldsSouth Shields 1-2 FC United of Manchester | Northern Premier League - Premier Division |
| 25 | Sat 18 Mar 2023 | 30-3 v MarineMarine 3-0 FC United of Manchester | Northern Premier League - Premier Division |
| 26 | Sat 25 Mar 2023 | 112-1 v Marske UnitedFC United of Manchester 2-1 Marske United | Northern Premier League - Premier Division |
| 27 | Sat 1 Apr 2023 | 31-0 v Morpeth TownMorpeth Town 0-1 FC United of Manchester | Northern Premier League - Premier Division |
| 28 | Sat 8 Apr 2023 | 35-2 v Bamber BridgeFC United of Manchester 5-2 Bamber Bridge | Northern Premier League - Premier Division |
| 29 | Mon 10 Apr 2023 | 35-0 v Ashton UnitedAshton United 0-5 FC United of Manchester | Northern Premier League - Premier Division |
| 30 | Sat 15 Apr 2023 | 30-1 v Stafford RangersFC United of Manchester 0-1 Stafford Rangers | Northern Premier League - Premier Division |
| 31 | Sat 22 Apr 2023 | 32-1 v Gainsborough TrinityGainsborough Trinity 1-2 FC United of Manchester | Northern Premier League - Premier Division |
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