| 1 | Tue 7 Sep 2021 | 23-2 v BootleFC United of Manchester 3-2 Bootle | Emirates FA Cup First Qualifying Round Replay |
| 2 | Sat 11 Sep 2021 | 41-3 v Stafford RangersFC United of Manchester 1-3 Stafford Rangers | Northern Premier League - Premier Division |
| 3 | Tue 14 Sep 2021 | 21-0 v Bamber BridgeFC United of Manchester 1-0 Bamber Bridge | Northern Premier League - Premier Division |
| 4 | Sat 18 Sep 2021 | 21-1 v Blyth SpartansBlyth Spartans 1-1 FC United of Manchester | Emirates FA Cup Second Qualifying Round |
| 5 | Tue 21 Sep 2021 | 140-2 v Blyth SpartansFC United of Manchester 0-2 Blyth Spartans | Emirates FA Cup Second Qualifying Round Replay |
| 6 | Sat 25 Sep 2021 | 22-5 v Stalybridge CelticStalybridge Celtic 5-2 FC United of Manchester | Northern Premier League - Premier Division |
| 7 | Tue 28 Sep 2021 | 46-0 v Scarborough AthleticFC United of Manchester 6-0 Scarborough Athletic | Northern Premier League - Premier Division |
| 8 | Sat 2 Oct 2021 | 40-1 v Matlock TownMatlock Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 9 | Tue 5 Oct 2021 | 21-0 v Basford UnitedBasford United 0-1 FC United of Manchester | Northern Premier League - Premier Division |
| 10 | Sat 9 Oct 2021 | 20-2 v Nantwich TownFC United of Manchester 0-2 Nantwich Town | Northern Premier League - Premier Division |
| 11 | Tue 12 Oct 2021 | 90-1 v Lancaster CityLancaster City 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 12 | Sat 16 Oct 2021 | 2 0-1 v Grantham TownFC United of Manchester 0-1 Grantham Town | Northern Premier League - Premier Division |
| 13 | Sat 23 Oct 2021 | 23-2 v Witton AlbionWitton Albion 2-3 FC United of Manchester | Northern Premier League - Premier Division |
| 14 | Sat 30 Oct 2021 | 15 2-0 v Runcorn LinnetsRuncorn Linnets 0-2 FC United of Manchester | Buildbase FA Trophy Third Qualifying Round |
| 15 | Tue 9 Nov 2021 | 70-1 v Whitby TownWhitby Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 16 | Sat 13 Nov 2021 | 162-3 v Marske UnitedMarske United 3-2 FC United of Manchester | Buildbase FA Trophy First Round |
| 17 | Sat 20 Nov 2021 | 2 1-2 v Atherton CollieriesAtherton Collieries 2-1 FC United of Manchester | Northern Premier League - Premier Division |
| 18 | Sat 27 Nov 2021 | 22-0 v MickleoverFC United of Manchester 2-0 Mickleover | Northern Premier League - Premier Division |
| 19 | Sat 18 Dec 2021 | 22-1 v BuxtonBuxton 1-2 FC United of Manchester | Northern Premier League - Premier Division |
| 20 | Mon 27 Dec 2021 | 24-3 v Ashton UnitedFC United of Manchester 4-3 Ashton United | Northern Premier League - Premier Division |
| 21 | Sat 1 Jan 2022 | 23-3 v RadcliffeRadcliffe 3-3 FC United of Manchester | Northern Premier League - Premier Division |
| 22 | Sat 15 Jan 2022 | 110-0 v Bamber BridgeBamber Bridge 0-0 FC United of Manchester | Northern Premier League - Premier Division |
| 23 | Sat 22 Jan 2022 | 142-1 v Stalybridge CelticFC United of Manchester 2-1 Stalybridge Celtic | Northern Premier League - Premier Division |
| 24 | Tue 25 Jan 2022 | 73-4 v Whitby TownFC United of Manchester 3-4 Whitby Town | Northern Premier League - Premier Division |
| 25 | Sat 29 Jan 2022 | 112-1 v Grantham TownGrantham Town 1-2 FC United of Manchester | Northern Premier League - Premier Division |
| 26 | Sat 5 Feb 2022 | 7 2-0 v Witton AlbionFC United of Manchester 2-0 Witton Albion | Northern Premier League - Premier Division |
| 27 | Sat 12 Feb 2022 | 7 2-3 v Gainsborough TrinityGainsborough Trinity 3-2 FC United of Manchester | Northern Premier League - Premier Division |
| 28 | Tue 15 Feb 2022 | 2 0-1 v Warrington TownFC United of Manchester 0-1 Warrington Town | Northern Premier League - Premier Division |
| 29 | Sat 19 Feb 2022 | 22-2 v Scarborough AthleticScarborough Athletic 2-2 FC United of Manchester | Northern Premier League - Premier Division |
| 30 | Sat 12 Mar 2022 | 120-2 v Nantwich TownNantwich Town 2-0 FC United of Manchester | Northern Premier League - Premier Division |
| 31 | Sat 19 Mar 2022 | 23-2 v Basford UnitedFC United of Manchester 3-2 Basford United | Northern Premier League - Premier Division |
| 32 | Sat 2 Apr 2022 | 72-0 v Atherton CollieriesFC United of Manchester 2-0 Atherton Collieries | Northern Premier League - Premier Division |
| 33 | Sat 9 Apr 2022 | 20-1 v Morpeth TownMorpeth Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 34 | Sat 16 Apr 2022 | 20-1 v South ShieldsFC United of Manchester 0-1 South Shields | Northern Premier League - Premier Division |
| 35 | Mon 18 Apr 2022 | 23-0 v Ashton UnitedAshton United 0-3 FC United of Manchester | Northern Premier League - Premier Division |
| 36 | Sat 23 Apr 2022 | 20-2 v Hyde UnitedFC United of Manchester 0-2 Hyde United | Northern Premier League - Premier Division |
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