| 1 | Tue 6 Aug | 21-2 v SV Red Bull SalzburgSV Red Bull Salzburg 2-1 FC Twente | UEFA Champions League Third Qualifying Round |
| 2 | Tue 13 Aug | 2 3-3 v SV Red Bull SalzburgFC Twente 3-3 SV Red Bull Salzburg | UEFA Champions League Third Qualifying Round |
| 3 | Sat 17 Aug | 2 1-1 v Sparta RotterdamFC Twente 1-1 Sparta Rotterdam | Dutch Eredivisie |
| 4 | Sun 1 Sep | 21-2 v FC UtrechtFC Utrecht 2-1 FC Twente | Dutch Eredivisie |
| 5 | Sat 14 Sep | 21-1 v PEC ZwolleFC Twente 1-1 PEC Zwolle | Dutch Eredivisie |
| 6 | Tue 17 Sep | 22-0 v sc HeerenveenFC Twente 2-0 sc Heerenveen | Dutch Eredivisie |
| 7 | Sun 22 Sep | 25-0 v Almere CityAlmere City 0-5 FC Twente | Dutch Eredivisie |
| 8 | Wed 25 Sep | 21-1 v Manchester UnitedManchester United 1-1 FC Twente | UEFA Europa League Matchday 1 |
| 9 | Sun 29 Sep | 21-0 v NAC BredaFC Twente 1-0 NAC Breda | Dutch Eredivisie |
| 10 | Thu 3 Oct | 2 1-1 v FenerbahçeFC Twente 1-1 Fenerbahçe | UEFA Europa League Matchday 2 |
| 11 | Sun 6 Oct | 2 1-2 v FeyenoordFeyenoord 2-1 FC Twente | Dutch Eredivisie |
| 12 | Sat 19 Oct | 22-2 v RKC WaalwijkRKC Waalwijk 2-2 FC Twente | Dutch Eredivisie |
| 13 | Thu 24 Oct | 20-2 v LazioFC Twente 0-2 Lazio | UEFA Europa League Matchday 3 |
| 14 | Sun 27 Oct | 25-0 v Heracles AlmeloFC Twente 5-0 Heracles Almelo | Dutch Eredivisie |
| 15 | Sat 2 Nov | 21-0 v Willem IIWillem II 0-1 FC Twente | Dutch Eredivisie |
| 16 | Sun 10 Nov | 22-2 v AjaxFC Twente 2-2 Ajax | Dutch Eredivisie |
| 17 | Sat 23 Nov | 2 2-1 v Fortuna SittardFortuna Sittard 1-2 FC Twente | Dutch Eredivisie |
| 18 | Thu 28 Nov | 20-1 v Union Saint-GilloiseFC Twente 0-1 Union Saint-Gilloise | UEFA Europa League Matchday 5 |
| 19 | Fri 6 Dec | 21-6 v PSV EindhovenPSV Eindhoven 6-1 FC Twente | Dutch Eredivisie |
| 20 | Thu 12 Dec | 20-0 v OlympiakosOlympiakos 0-0 FC Twente | UEFA Europa League Matchday 6 |
| 21 | Sun 2 Feb | 22-2 v Go Ahead EaglesGo Ahead Eagles 2-2 FC Twente | Dutch Eredivisie |
| 22 | Sun 9 Feb | 23-3 v sc Heerenveensc Heerenveen 3-3 FC Twente | Dutch Eredivisie |
| 23 | Thu 13 Feb | 22-1 v FK Bodø/GlimtFC Twente 2-1 FK Bodø/Glimt | UEFA Europa League Knockout Round |
| 24 | Thu 20 Feb | 2 2-5 v FK Bodø/GlimtFK Bodø/Glimt 5-2 FC Twente | UEFA Europa League Knockout Round |
| 25 | Sat 1 Mar | 21-1 v FC GroningenFC Groningen 1-1 FC Twente | Dutch Eredivisie |
| 26 | Sun 9 Mar | 21-0 v Almere CityFC Twente 1-0 Almere City | Dutch Eredivisie |
| 27 | Sun 16 Mar | 2 2-6 v FeyenoordFC Twente 2-6 Feyenoord | Dutch Eredivisie |
| 28 | Sun 30 Mar | 21-2 v Heracles AlmeloHeracles Almelo 2-1 FC Twente | Dutch Eredivisie |
| 29 | Sat 5 Apr | 21-1 v Fortuna SittardFC Twente 1-1 Fortuna Sittard | Dutch Eredivisie |
| 30 | Sun 13 Apr | 2 1-1 v PEC ZwollePEC Zwolle 1-1 FC Twente | Dutch Eredivisie |
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