| 1 | Tue 6 Aug | 11-2 v SV Red Bull SalzburgSV Red Bull Salzburg 2-1 FC Twente | UEFA Champions League Third Qualifying Round |
| 2 | Sat 10 Aug | 12-1 v NEC NijmegenNEC Nijmegen 1-2 FC Twente | Dutch Eredivisie |
| 3 | Tue 13 Aug | 13-3 v SV Red Bull SalzburgFC Twente 3-3 SV Red Bull Salzburg | UEFA Champions League Third Qualifying Round |
| 4 | Sat 17 Aug | 11-1 v Sparta RotterdamFC Twente 1-1 Sparta Rotterdam | Dutch Eredivisie |
| 5 | Sun 1 Sep | 11-2 v FC UtrechtFC Utrecht 2-1 FC Twente | Dutch Eredivisie |
| 6 | Sat 14 Sep | 11-1 v PEC ZwolleFC Twente 1-1 PEC Zwolle | Dutch Eredivisie |
| 7 | Tue 17 Sep | 12-0 v sc HeerenveenFC Twente 2-0 sc Heerenveen | Dutch Eredivisie |
| 8 | Sun 22 Sep | 15-0 v Almere CityAlmere City 0-5 FC Twente | Dutch Eredivisie |
| 9 | Wed 25 Sep | 11-1 v Manchester UnitedManchester United 1-1 FC Twente | UEFA Europa League Matchday 1 |
| 10 | Sun 29 Sep | 11-0 v NAC BredaFC Twente 1-0 NAC Breda | Dutch Eredivisie |
| 11 | Thu 3 Oct | 11-1 v FenerbahçeFC Twente 1-1 Fenerbahçe | UEFA Europa League Matchday 2 |
| 12 | Sun 6 Oct | 11-2 v FeyenoordFeyenoord 2-1 FC Twente | Dutch Eredivisie |
| 13 | Sat 19 Oct | 12-2 v RKC WaalwijkRKC Waalwijk 2-2 FC Twente | Dutch Eredivisie |
| 14 | Thu 24 Oct | 1 0-2 v LazioFC Twente 0-2 Lazio | UEFA Europa League Matchday 3 |
| 15 | Sun 27 Oct | 15-0 v Heracles AlmeloFC Twente 5-0 Heracles Almelo | Dutch Eredivisie |
| 16 | Sat 2 Nov | 11-0 v Willem IIWillem II 0-1 FC Twente | Dutch Eredivisie |
| 17 | Sun 10 Nov | 12-2 v AjaxFC Twente 2-2 Ajax | Dutch Eredivisie |
| 18 | Sat 23 Nov | 12-1 v Fortuna SittardFortuna Sittard 1-2 FC Twente | Dutch Eredivisie |
| 19 | Thu 28 Nov | 10-1 v Union Saint-GilloiseFC Twente 0-1 Union Saint-Gilloise | UEFA Europa League Matchday 5 |
| 20 | Sun 1 Dec | 13-2 v Go Ahead EaglesFC Twente 3-2 Go Ahead Eagles | Dutch Eredivisie |
| 21 | Thu 12 Dec | 10-0 v OlympiakosOlympiakos 0-0 FC Twente | UEFA Europa League Matchday 6 |
| 22 | Sun 15 Dec | 12-0 v FC GroningenFC Twente 2-0 FC Groningen | Dutch Eredivisie |
| 23 | Sat 21 Dec | 10-1 v AZ AlkmaarAZ Alkmaar 1-0 FC Twente | Dutch Eredivisie |
| 24 | Sun 12 Jan | 16-2 v Willem IIFC Twente 6-2 Willem II | Dutch Eredivisie |
| 25 | Sun 19 Jan | 11-2 v NAC BredaNAC Breda 2-1 FC Twente | Dutch Eredivisie |
| 26 | Thu 23 Jan | 13-2 v Malmö FFMalmö FF 2-3 FC Twente | UEFA Europa League Matchday 7 |
| 27 | Thu 30 Jan | 11-0 v BeşiktaşFC Twente 1-0 Beşiktaş | UEFA Europa League Matchday 8 |
| 28 | Sun 2 Feb | 12-2 v Go Ahead EaglesGo Ahead Eagles 2-2 FC Twente | Dutch Eredivisie |
| 29 | Sun 9 Feb | 13-3 v sc Heerenveensc Heerenveen 3-3 FC Twente | Dutch Eredivisie |
| 30 | Thu 13 Feb | 12-1 v FK Bodø/GlimtFC Twente 2-1 FK Bodø/Glimt | UEFA Europa League Knockout Round |
| 31 | Sun 16 Feb | 12-0 v RKC WaalwijkFC Twente 2-0 RKC Waalwijk | Dutch Eredivisie |
| 32 | Thu 20 Feb | 12-5 v FK Bodø/GlimtFK Bodø/Glimt 5-2 FC Twente | UEFA Europa League Knockout Round |
| 33 | Sun 23 Feb | 12-0 v NEC NijmegenFC Twente 2-0 NEC Nijmegen | Dutch Eredivisie |
| 34 | Sat 1 Mar | 11-1 v FC GroningenFC Groningen 1-1 FC Twente | Dutch Eredivisie |
| 35 | Sun 9 Mar | 11-0 v Almere CityFC Twente 1-0 Almere City | Dutch Eredivisie |
| 36 | Sun 16 Mar | 12-6 v FeyenoordFC Twente 2-6 Feyenoord | Dutch Eredivisie |
| 37 | Sun 30 Mar | 11-2 v Heracles AlmeloHeracles Almelo 2-1 FC Twente | Dutch Eredivisie |
| 38 | Sat 5 Apr | 11-1 v Fortuna SittardFC Twente 1-1 Fortuna Sittard | Dutch Eredivisie |
| 39 | Sun 13 Apr | 11-1 v PEC ZwollePEC Zwolle 1-1 FC Twente | Dutch Eredivisie |
| 40 | Thu 24 Apr | 11-3 v PSV EindhovenFC Twente 1-3 PSV Eindhoven | Dutch Eredivisie |
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