| 1 | Thu 4 Aug 2022 | 43-1 v ČukaričkiČukarički 1-3 FC Twente | UEFA Europa Conference League Third Qualifying Round |
| 2 | Sun 7 Aug 2022 | 41-0 v NEC NijmegenNEC Nijmegen 0-1 FC Twente | Dutch Eredivisie |
| 3 | Sun 14 Aug 2022 | 43-0 v Fortuna SittardFC Twente 3-0 Fortuna Sittard | Dutch Eredivisie |
| 4 | Thu 18 Aug 2022 | 41-2 v FiorentinaFiorentina 2-1 FC Twente | UEFA Europa Conference League Play-off |
| 5 | Sun 18 Sep 2022 | 41-2 v sc Heerenveensc Heerenveen 2-1 FC Twente | Dutch Eredivisie |
| 6 | Sat 1 Oct 2022 | 43-0 v VitesseFC Twente 3-0 Vitesse | Dutch Eredivisie |
| 7 | Sun 9 Oct 2022 | 40-2 v FeyenoordFeyenoord 2-0 FC Twente | Dutch Eredivisie |
| 8 | Sun 16 Oct 2022 | 43-0 v FC GroningenFC Twente 3-0 FC Groningen | Dutch Eredivisie |
| 9 | Sun 6 Nov 2022 | 41-1 v Go Ahead EaglesFC Twente 1-1 Go Ahead Eagles | Dutch Eredivisie |
| 10 | Fri 11 Nov 2022 | 41-1 v Sparta RotterdamSparta Rotterdam 1-1 FC Twente | Dutch Eredivisie |
| 11 | Fri 6 Jan 2023 | 42-0 v FC EmmenFC Twente 2-0 FC Emmen | Dutch Eredivisie |
| 12 | Sun 22 Jan 2023 | 42-0 v FC UtrechtFC Twente 2-0 FC Utrecht | Dutch Eredivisie |
| 13 | Wed 25 Jan 2023 | 42-2 v VitesseVitesse 2-2 FC Twente | Dutch Eredivisie |
| 14 | Sun 26 Feb 2023 | 41-3 v PSV EindhovenPSV Eindhoven 3-1 FC Twente | Dutch Eredivisie |
| 15 | Sat 4 Mar 2023 | 43-3 v sc HeerenveenFC Twente 3-3 sc Heerenveen | Dutch Eredivisie |
| 16 | Sat 11 Mar 2023 | 43-0 v Fortuna SittardFortuna Sittard 0-3 FC Twente | Dutch Eredivisie |
| 17 | Sun 19 Mar 2023 | 4 2-1 v AZ AlkmaarFC Twente 2-1 AZ Alkmaar | Dutch Eredivisie |
| 18 | Sat 1 Apr 2023 | 40-0 v Excelsior RotterdamExcelsior Rotterdam 0-0 FC Twente | Dutch Eredivisie |
| 19 | Sun 9 Apr 2023 | 44-0 v SC CambuurFC Twente 4-0 SC Cambuur | Dutch Eredivisie |
| 20 | Sun 16 Apr 2023 | 40-1 v FC UtrechtFC Utrecht 1-0 FC Twente | Dutch Eredivisie |
| 21 | Sun 23 Apr 2023 | 43-3 v Sparta RotterdamFC Twente 3-3 Sparta Rotterdam | Dutch Eredivisie |
| 22 | Sun 7 May 2023 | 43-0 v FC EmmenFC Emmen 0-3 FC Twente | Dutch Eredivisie |
| 23 | Fri 12 May 2023 | 44-0 v NEC NijmegenFC Twente 4-0 NEC Nijmegen | Dutch Eredivisie |
| 24 | Sun 21 May 2023 | 45-0 v RKC WaalwijkRKC Waalwijk 0-5 FC Twente | Dutch Eredivisie |
| 25 | Sun 28 May 2023 | 43-1 v AjaxFC Twente 3-1 Ajax | Dutch Eredivisie |
| 26 | Thu 1 Jun 2023 | 42-1 v sc Heerenveensc Heerenveen 1-2 FC Twente | Dutch Eredivisie Play-off |
| 27 | Sun 4 Jun 2023 | 44-0 v sc HeerenveenFC Twente 4-0 sc Heerenveen | Dutch Eredivisie Play-off |
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