| 1 | Sun 7 Aug 2022 | 41-3 v 1 FC Köln1 FC Köln 3-1 FC Schalke 04 | German Bundesliga |
| 2 | Sat 13 Aug 2022 | 42-2 v Borussia MönchengladbachFC Schalke 04 2-2 Borussia Mönchengladbach | German Bundesliga |
| 3 | Sat 20 Aug 2022 | 40-0 v VfL WolfsburgVfL Wolfsburg 0-0 FC Schalke 04 | German Bundesliga |
| 4 | Sat 27 Aug 2022 | 41-6 v 1 FC Union BerlinFC Schalke 04 1-6 1 FC Union Berlin | German Bundesliga |
| 5 | Sat 3 Sep 2022 | 41-1 v VfB StuttgartVfB Stuttgart 1-1 FC Schalke 04 | German Bundesliga |
| 6 | Sat 10 Sep 2022 | 43-1 v VfL BochumFC Schalke 04 3-1 VfL Bochum | German Bundesliga |
| 7 | Sat 17 Sep 2022 | 40-1 v Borussia DortmundBorussia Dortmund 1-0 FC Schalke 04 | German Bundesliga |
| 8 | Sun 2 Oct 2022 | 42-3 v FC AugsburgFC Schalke 04 2-3 FC Augsburg | German Bundesliga |
| 9 | Sat 8 Oct 2022 | 4 0-4 v Bayer 04 LeverkusenBayer 04 Leverkusen 4-0 FC Schalke 04 | German Bundesliga |
| 10 | Fri 14 Oct 2022 | 40-3 v 1899 HoffenheimFC Schalke 04 0-3 1899 Hoffenheim | German Bundesliga |
| 11 | Sun 23 Oct 2022 | 41-2 v Hertha BerlinHertha Berlin 2-1 FC Schalke 04 | German Bundesliga |
| 12 | Sun 30 Oct 2022 | 4 0-2 v SC FreiburgFC Schalke 04 0-2 SC Freiburg | German Bundesliga |
| 13 | Sat 5 Nov 2022 | 41-2 v Werder BremenWerder Bremen 2-1 FC Schalke 04 | German Bundesliga |
| 14 | Wed 9 Nov 2022 | 4 1-0 v Mainz 05FC Schalke 04 1-0 Mainz 05 | German Bundesliga |
| 15 | Sat 12 Nov 2022 | 40-2 v Bayern MunichFC Schalke 04 0-2 Bayern Munich | German Bundesliga |
| 16 | Sat 21 Jan 2023 | 40-3 v Eintracht FrankfurtEintracht Frankfurt 3-0 FC Schalke 04 | German Bundesliga |
| 17 | Tue 24 Jan 2023 | 41-6 v RB LeipzigFC Schalke 04 1-6 RB Leipzig | German Bundesliga |
| 18 | Sun 29 Jan 2023 | 40-0 v 1 FC KölnFC Schalke 04 0-0 1 FC Köln | German Bundesliga |
| 19 | Sat 4 Feb 2023 | 40-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-0 FC Schalke 04 | German Bundesliga |
| 20 | Fri 10 Feb 2023 | 40-0 v VfL WolfsburgFC Schalke 04 0-0 VfL Wolfsburg | German Bundesliga |
| 21 | Sun 19 Feb 2023 | 40-0 v 1 FC Union Berlin1 FC Union Berlin 0-0 FC Schalke 04 | German Bundesliga |
| 22 | Sat 25 Feb 2023 | 42-1 v VfB StuttgartFC Schalke 04 2-1 VfB Stuttgart | German Bundesliga |
| 23 | Sat 4 Mar 2023 | 42-0 v VfL BochumVfL Bochum 0-2 FC Schalke 04 | German Bundesliga |
| 24 | Sat 11 Mar 2023 | 42-2 v Borussia DortmundFC Schalke 04 2-2 Borussia Dortmund | German Bundesliga |
| 25 | Sat 18 Mar 2023 | 41-1 v FC AugsburgFC Augsburg 1-1 FC Schalke 04 | German Bundesliga |
| 26 | Sat 1 Apr 2023 | 40-3 v Bayer 04 LeverkusenFC Schalke 04 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 27 | Sun 9 Apr 2023 | 40-2 v 1899 Hoffenheim1899 Hoffenheim 2-0 FC Schalke 04 | German Bundesliga |
| 28 | Sat 29 Apr 2023 | 4 2-1 v Werder BremenFC Schalke 04 2-1 Werder Bremen | German Bundesliga |
| 29 | Sat 13 May 2023 | 40-6 v Bayern MunichBayern Munich 6-0 FC Schalke 04 | German Bundesliga |
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