| 1 | Tue 10 Aug 2021 | 20-0 v Wycombe WanderersExeter City 0-0 Wycombe Wanderers | Carabao Cup First Round |
| 2 | Tue 17 Aug 2021 | 20-0 v BarrowBarrow 0-0 Exeter City | Sky Bet League Two |
| 3 | Sat 21 Aug 2021 | 24-1 v Bristol RoversExeter City 4-1 Bristol Rovers | Sky Bet League Two |
| 4 | Sat 28 Aug 2021 | 21-1 v Harrogate TownHarrogate Town 1-1 Exeter City | Sky Bet League Two |
| 5 | Sat 4 Sep 2021 | 20-0 v Forest Green RoversExeter City 0-0 Forest Green Rovers | Sky Bet League Two |
| 6 | Sat 11 Sep 2021 | 24-0 v Scunthorpe UnitedScunthorpe United 0-4 Exeter City | Sky Bet League Two |
| 7 | Sat 18 Sep 2021 | 22-0 v Sutton UnitedExeter City 2-0 Sutton United | Sky Bet League Two |
| 8 | Sat 25 Sep 2021 | 21-1 v Hartlepool UnitedHartlepool United 1-1 Exeter City | Sky Bet League Two |
| 9 | Sat 2 Oct 2021 | 22-2 v WalsallExeter City 2-2 Walsall | Sky Bet League Two |
| 10 | Tue 5 Oct 2021 | 22-2 v Cheltenham TownCheltenham Town 2-2 Exeter City | Papa John’s Trophy |
| 11 | Sat 9 Oct 2021 | 22-2 v StevenageStevenage 2-2 Exeter City | Sky Bet League Two |
| 12 | Sat 16 Oct 2021 | 22-2 v Newport CountyExeter City 2-2 Newport County | Sky Bet League Two |
| 13 | Tue 19 Oct 2021 | 23-1 v Crawley TownCrawley Town 1-3 Exeter City | Sky Bet League Two |
| 14 | Sat 30 Oct 2021 | 22-1 v Salford CitySalford City 1-2 Exeter City | Sky Bet League Two |
| 15 | Sat 6 Nov 2021 | 21-1 v Bradford CityBradford City 1-1 Exeter City | Emirates FA Cup First Round |
| 16 | Wed 10 Nov 2021 | 25-3 v Bristol RoversExeter City 5-3 Bristol Rovers | Papa John’s Trophy |
| 17 | Sat 13 Nov 2021 | 22-1 v Oldham AthleticExeter City 2-1 Oldham Athletic | Sky Bet League Two |
| 18 | Tue 16 Nov 2021 | 23-0 v Bradford CityExeter City 3-0 Bradford City | Emirates FA Cup |
| 19 | Sat 20 Nov 2021 | 22-1 v Carlisle UnitedExeter City 2-1 Carlisle United | Sky Bet League Two |
| 20 | Tue 23 Nov 2021 | 21-3 v Colchester UnitedColchester United 3-1 Exeter City | Sky Bet League Two |
| 21 | Sat 27 Nov 2021 | 21-1 v RochdaleRochdale 1-1 Exeter City | Sky Bet League Two |
| 22 | Sat 4 Dec 2021 | 2 1-2 v Cambridge UnitedCambridge United 2-1 Exeter City | Emirates FA Cup Second Round |
| 23 | Tue 7 Dec 2021 | 2 1-2 v Northampton TownExeter City 1-2 Northampton Town | Sky Bet League Two |
| 24 | Sat 11 Dec 2021 | 20-1 v Tranmere RoversExeter City 0-1 Tranmere Rovers | Sky Bet League Two |
| 25 | Sat 1 Jan 2022 | 21-2 v Sutton UnitedSutton United 2-1 Exeter City | Sky Bet League Two |
| 26 | Tue 4 Jan 2022 | 20-0 v Forest Green RoversForest Green Rovers 0-0 Exeter City | Sky Bet League Two |
| 27 | Fri 7 Jan 2022 | 22-3 v PortsmouthExeter City 2-3 Portsmouth | Papa John’s Trophy Second Round |
| 28 | Sat 15 Jan 2022 | 22-0 v Scunthorpe UnitedExeter City 2-0 Scunthorpe United | Sky Bet League Two |
| 29 | Sat 22 Jan 2022 | 22-0 v WalsallWalsall 0-2 Exeter City | Sky Bet League Two |
| 30 | Sat 29 Jan 2022 | 20-0 v Hartlepool UnitedExeter City 0-0 Hartlepool United | Sky Bet League Two |
| 31 | Sat 5 Feb 2022 | 22-1 v Swindon TownSwindon Town 1-2 Exeter City | Sky Bet League Two |
| 32 | Sat 12 Feb 2022 | 2 1-0 v Bradford CityBradford City 0-1 Exeter City | Sky Bet League Two |
| 33 | Tue 15 Feb 2022 | 24-3 v Harrogate TownExeter City 4-3 Harrogate Town | Sky Bet League Two |
| 34 | Sat 26 Feb 2022 | 21-1 v Bristol RoversBristol Rovers 1-1 Exeter City | Sky Bet League Two |
| 35 | Fri 4 Mar 2022 | 21-2 v Mansfield TownMansfield Town 2-1 Exeter City | Sky Bet League Two |
| 36 | Sat 19 Mar 2022 | 22-0 v Oldham AthleticOldham Athletic 0-2 Exeter City | Sky Bet League Two |
| 37 | Tue 22 Mar 2022 | 20-0 v Port ValePort Vale 0-0 Exeter City | Sky Bet League Two |
| 38 | Sat 9 Apr 2022 | 21-0 v Carlisle UnitedCarlisle United 0-1 Exeter City | Sky Bet League Two |
| 39 | Sat 23 Apr 2022 | 22-0 v RochdaleExeter City 2-0 Rochdale | Sky Bet League Two |
| 40 | Sat 30 Apr 2022 | 21-1 v Northampton TownNorthampton Town 1-1 Exeter City | Sky Bet League Two |
| 41 | Sat 7 May 2022 | 20-1 v Port ValeExeter City 0-1 Port Vale | Sky Bet League Two |
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