| 1 | Sat 14 Aug 2021 | 10-2 v PortsmouthPortsmouth 2-0 Crewe Alexandra | Sky Bet League One |
| 2 | Tue 24 Aug 2021 | 10-3 v Leeds UnitedLeeds United 3-0 Crewe Alexandra | Carabao Cup Second Round |
| 3 | Sat 28 Aug 2021 | 10-2 v Charlton AthleticCharlton Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 4 | Sat 11 Sep 2021 | 11-1 v Shrewsbury TownShrewsbury Town 1-1 Crewe Alexandra | Sky Bet League One |
| 5 | Sat 18 Sep 2021 | 12-0 v Burton AlbionCrewe Alexandra 2-0 Burton Albion | Sky Bet League One |
| 6 | Tue 21 Sep 2021 | 11-3 v MorecambeCrewe Alexandra 1-3 Morecambe | Sky Bet League One |
| 7 | Sat 25 Sep 2021 | 1 1-1 v Rotherham UnitedRotherham United 1-1 Crewe Alexandra | Sky Bet League One |
| 8 | Tue 28 Sep 2021 | 11-1 v Plymouth ArgylePlymouth Argyle 1-1 Crewe Alexandra | Sky Bet League One |
| 9 | Sat 2 Oct 2021 | 12-2 v Cambridge UnitedCrewe Alexandra 2-2 Cambridge United | Sky Bet League One |
| 10 | Sat 16 Oct 2021 | 10-3 v Fleetwood TownFleetwood Town 3-0 Crewe Alexandra | Sky Bet League One |
| 11 | Tue 19 Oct 2021 | 10-4 v SunderlandCrewe Alexandra 0-4 Sunderland | Sky Bet League One |
| 12 | Sat 23 Oct 2021 | 11-2 v Wycombe WanderersWycombe Wanderers 2-1 Crewe Alexandra | Sky Bet League One |
| 13 | Sat 30 Oct 2021 | 11-4 v Milton Keynes DonsCrewe Alexandra 1-4 Milton Keynes Dons | Sky Bet League One |
| 14 | Tue 4 Jan 2022 | 12-4 v Rotherham UnitedCrewe Alexandra 2-4 Rotherham United | Papa John’s Trophy Third Round |
| 15 | Tue 1 Feb 2022 | 10-1 v GillinghamGillingham 1-0 Crewe Alexandra | Sky Bet League One |
| 16 | Tue 8 Feb 2022 | 11-4 v Plymouth ArgyleCrewe Alexandra 1-4 Plymouth Argyle | Sky Bet League One |
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