| 1 | Tue 17 Aug 2021 | 50-1 v Oxford UnitedOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 2 | Sat 21 Aug 2021 | 50-1 v Accrington StanleyCrewe Alexandra 0-1 Accrington Stanley | Sky Bet League One |
| 3 | Tue 24 Aug 2021 | 50-3 v Leeds UnitedLeeds United 3-0 Crewe Alexandra | Carabao Cup Second Round |
| 4 | Sat 28 Aug 2021 | 50-2 v Charlton AthleticCharlton Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 5 | Sat 11 Sep 2021 | 51-1 v Shrewsbury TownShrewsbury Town 1-1 Crewe Alexandra | Sky Bet League One |
| 6 | Sat 18 Sep 2021 | 52-0 v Burton AlbionCrewe Alexandra 2-0 Burton Albion | Sky Bet League One |
| 7 | Tue 21 Sep 2021 | 51-3 v MorecambeCrewe Alexandra 1-3 Morecambe | Sky Bet League One |
| 8 | Tue 28 Sep 2021 | 51-1 v Plymouth ArgylePlymouth Argyle 1-1 Crewe Alexandra | Sky Bet League One |
| 9 | Tue 5 Oct 2021 | 52-0 v Wigan AthleticCrewe Alexandra 2-0 Wigan Athletic | Papa John’s Trophy |
| 10 | Sat 16 Oct 2021 | 5 0-3 v Fleetwood TownFleetwood Town 3-0 Crewe Alexandra | Sky Bet League One |
| 11 | Tue 19 Oct 2021 | 50-4 v SunderlandCrewe Alexandra 0-4 Sunderland | Sky Bet League One |
| 12 | Tue 2 Nov 2021 | 51-1 v Doncaster RoversCrewe Alexandra 1-1 Doncaster Rovers | Sky Bet League One |
| 13 | Sat 6 Nov 2021 | 50-3 v Swindon TownCrewe Alexandra 0-3 Swindon Town | Emirates FA Cup First Round |
| 14 | Fri 12 Nov 2021 | 50-2 v Bolton WanderersBolton Wanderers 2-0 Crewe Alexandra | Sky Bet League One |
| 15 | Sat 20 Nov 2021 | 52-0 v GillinghamCrewe Alexandra 2-0 Gillingham | Sky Bet League One |
| 16 | Tue 23 Nov 2021 | 52-3 v AFC WimbledonAFC Wimbledon 3-2 Crewe Alexandra | Sky Bet League One |
| 17 | Tue 4 Jan 2022 | 52-4 v Rotherham UnitedCrewe Alexandra 2-4 Rotherham United | Papa John’s Trophy Third Round |
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