| 1 | Tue 8 Feb 2022 | 41-4 v Plymouth ArgyleCrewe Alexandra 1-4 Plymouth Argyle | Sky Bet League One |
| 2 | Sat 12 Feb 2022 | 41-4 v Accrington StanleyAccrington Stanley 4-1 Crewe Alexandra | Sky Bet League One |
| 3 | Tue 22 Feb 2022 | 40-1 v Oxford UnitedCrewe Alexandra 0-1 Oxford United | Sky Bet League One |
| 4 | Sat 26 Feb 2022 | 42-1 v Cheltenham TownCheltenham Town 1-2 Crewe Alexandra | Sky Bet League One |
| 5 | Sat 5 Mar 2022 | 41-3 v Wycombe WanderersCrewe Alexandra 1-3 Wycombe Wanderers | Sky Bet League One |
| 6 | Tue 8 Mar 2022 | 41-3 v PortsmouthCrewe Alexandra 1-3 Portsmouth | Sky Bet League One |
| 7 | Sat 12 Mar 2022 | 40-2 v SunderlandSunderland 2-0 Crewe Alexandra | Sky Bet League One |
| 8 | Tue 15 Mar 2022 | 40-2 v Wigan AthleticCrewe Alexandra 0-2 Wigan Athletic | Sky Bet League One |
| 9 | Sat 19 Mar 2022 | 40-1 v Bolton WanderersCrewe Alexandra 0-1 Bolton Wanderers | Sky Bet League One |
| 10 | Sat 2 Apr 2022 | 41-3 v Fleetwood TownCrewe Alexandra 1-3 Fleetwood Town | Sky Bet League One |
| 11 | Tue 5 Apr 2022 | 41-2 v Milton Keynes DonsMilton Keynes Dons 2-1 Crewe Alexandra | Sky Bet League One |
| 12 | Sat 9 Apr 2022 | 40-2 v Doncaster RoversDoncaster Rovers 2-0 Crewe Alexandra | Sky Bet League One |
| 13 | Fri 15 Apr 2022 | 43-1 v AFC WimbledonCrewe Alexandra 3-1 AFC Wimbledon | Sky Bet League One |
| 14 | Tue 19 Apr 2022 | 40-1 v Sheffield WednesdaySheffield Wednesday 1-0 Crewe Alexandra | Sky Bet League One |
| 15 | Sat 30 Apr 2022 | 41-2 v Lincoln CityLincoln City 2-1 Crewe Alexandra | Sky Bet League One |
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