| 1 | Sat 7 Aug 2021 | 201-1 v Cheltenham TownCrewe Alexandra 1-1 Cheltenham Town | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 200-2 v PortsmouthPortsmouth 2-0 Crewe Alexandra | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 20 0-1 v Oxford UnitedOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 4 | Tue 24 Aug 2021 | 200-3 v Leeds UnitedLeeds United 3-0 Crewe Alexandra | Carabao Cup Second Round |
| 5 | Sat 28 Aug 2021 | 200-2 v Charlton AthleticCharlton Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 6 | Tue 31 Aug 2021 | 201-0 v Shrewsbury TownShrewsbury Town 0-1 Crewe Alexandra | Papa John’s Trophy |
| 7 | Sat 18 Sep 2021 | 202-0 v Burton AlbionCrewe Alexandra 2-0 Burton Albion | Sky Bet League One |
| 8 | Tue 21 Sep 2021 | 201-3 v MorecambeCrewe Alexandra 1-3 Morecambe | Sky Bet League One |
| 9 | Sat 25 Sep 2021 | 201-1 v Rotherham UnitedRotherham United 1-1 Crewe Alexandra | Sky Bet League One |
| 10 | Tue 28 Sep 2021 | 201-1 v Plymouth ArgylePlymouth Argyle 1-1 Crewe Alexandra | Sky Bet League One |
| 11 | Sat 2 Oct 2021 | 202-2 v Cambridge UnitedCrewe Alexandra 2-2 Cambridge United | Sky Bet League One |
| 12 | Tue 5 Oct 2021 | 202-0 v Wigan AthleticCrewe Alexandra 2-0 Wigan Athletic | Papa John’s Trophy |
| 13 | Sat 6 Nov 2021 | 200-3 v Swindon TownCrewe Alexandra 0-3 Swindon Town | Emirates FA Cup First Round |
| 14 | Sat 15 Jan 2022 | 200-0 v Shrewsbury TownCrewe Alexandra 0-0 Shrewsbury Town | Sky Bet League One |
| 15 | Tue 22 Feb 2022 | 200-1 v Oxford UnitedCrewe Alexandra 0-1 Oxford United | Sky Bet League One |
| 16 | Sat 26 Feb 2022 | 202-1 v Cheltenham TownCheltenham Town 1-2 Crewe Alexandra | Sky Bet League One |
| 17 | Sat 5 Mar 2022 | 201-3 v Wycombe WanderersCrewe Alexandra 1-3 Wycombe Wanderers | Sky Bet League One |
| 18 | Tue 8 Mar 2022 | 201-3 v PortsmouthCrewe Alexandra 1-3 Portsmouth | Sky Bet League One |
| 19 | Sat 12 Mar 2022 | 20 0-2 v SunderlandSunderland 2-0 Crewe Alexandra | Sky Bet League One |
| 20 | Tue 15 Mar 2022 | 200-2 v Wigan AthleticCrewe Alexandra 0-2 Wigan Athletic | Sky Bet League One |
| 21 | Sat 19 Mar 2022 | 200-1 v Bolton WanderersCrewe Alexandra 0-1 Bolton Wanderers | Sky Bet League One |
| 22 | Tue 5 Apr 2022 | 201-2 v Milton Keynes DonsMilton Keynes Dons 2-1 Crewe Alexandra | Sky Bet League One |
| 23 | Sat 9 Apr 2022 | 200-2 v Doncaster RoversDoncaster Rovers 2-0 Crewe Alexandra | Sky Bet League One |
| 24 | Fri 15 Apr 2022 | 203-1 v AFC WimbledonCrewe Alexandra 3-1 AFC Wimbledon | Sky Bet League One |
| 25 | Tue 19 Apr 2022 | 200-1 v Sheffield WednesdaySheffield Wednesday 1-0 Crewe Alexandra | Sky Bet League One |
| 26 | Sat 30 Apr 2022 | 201-2 v Lincoln CityLincoln City 2-1 Crewe Alexandra | Sky Bet League One |
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