| 1 | Tue 4 Jan 2022 | 292-4 v Rotherham UnitedCrewe Alexandra 2-4 Rotherham United | Papa John’s Trophy Third Round |
| 2 | Sat 29 Jan 2022 | 290-2 v Rotherham UnitedCrewe Alexandra 0-2 Rotherham United | Sky Bet League One |
| 3 | Sat 12 Feb 2022 | 291-4 v Accrington StanleyAccrington Stanley 4-1 Crewe Alexandra | Sky Bet League One |
| 4 | Tue 15 Feb 2022 | 290-2 v Wigan AthleticWigan Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 5 | Tue 22 Feb 2022 | 290-1 v Oxford UnitedCrewe Alexandra 0-1 Oxford United | Sky Bet League One |
| 6 | Sat 26 Feb 2022 | 292-1 v Cheltenham TownCheltenham Town 1-2 Crewe Alexandra | Sky Bet League One |
| 7 | Sat 5 Mar 2022 | 291-3 v Wycombe WanderersCrewe Alexandra 1-3 Wycombe Wanderers | Sky Bet League One |
| 8 | Tue 8 Mar 2022 | 291-3 v PortsmouthCrewe Alexandra 1-3 Portsmouth | Sky Bet League One |
| 9 | Sat 12 Mar 2022 | 290-2 v SunderlandSunderland 2-0 Crewe Alexandra | Sky Bet League One |
| 10 | Tue 15 Mar 2022 | 290-2 v Wigan AthleticCrewe Alexandra 0-2 Wigan Athletic | Sky Bet League One |
| 11 | Sat 2 Apr 2022 | 291-3 v Fleetwood TownCrewe Alexandra 1-3 Fleetwood Town | Sky Bet League One |
| 12 | Tue 5 Apr 2022 | 291-2 v Milton Keynes DonsMilton Keynes Dons 2-1 Crewe Alexandra | Sky Bet League One |
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