| 1 | Tue 7 Sep 2021 | 220-1 v GillinghamColchester United 0-1 Gillingham | Papa John’s Trophy |
| 2 | Fri 10 Sep 2021 | 223-2 v BarrowBarrow 2-3 Colchester United | Sky Bet League Two |
| 3 | Sat 16 Oct 2021 | 221-0 v Harrogate TownColchester United 1-0 Harrogate Town | Sky Bet League Two |
| 4 | Tue 19 Oct 2021 | 22 1-1 v Bristol RoversColchester United 1-1 Bristol Rovers | Sky Bet League Two |
| 5 | Tue 9 Nov 2021 | 220-0 v Ipswich TownIpswich Town 0-0 Colchester United | Papa John’s Trophy |
| 6 | Sat 20 Nov 2021 | 22 0-1 v StevenageStevenage 1-0 Colchester United | Sky Bet League Two |
| 7 | Tue 23 Nov 2021 | 22 3-1 v Exeter CityColchester United 3-1 Exeter City | Sky Bet League Two |
| 8 | Sun 5 Dec 2021 | 221-2 v Wigan AthleticColchester United 1-2 Wigan Athletic | Emirates FA Cup Second Round |
| 9 | Wed 8 Dec 2021 | 220-0 v Bradford CityBradford City 0-0 Colchester United | Sky Bet League Two |
| 10 | Sat 11 Dec 2021 | 220-3 v WalsallWalsall 3-0 Colchester United | Sky Bet League Two |
| 11 | Sat 1 Jan 2022 | 221-3 v Crawley TownCrawley Town 3-1 Colchester United | Sky Bet League Two |
| 12 | Tue 4 Jan 2022 | 221-2 v Sutton UnitedSutton United 2-1 Colchester United | Papa John’s Trophy Third Round |
| 13 | Tue 11 Jan 2022 | 220-2 v Forest Green RoversForest Green Rovers 2-0 Colchester United | Sky Bet League Two |
| 14 | Sat 15 Jan 2022 | 220-2 v BarrowColchester United 0-2 Barrow | Sky Bet League Two |
| 15 | Sat 22 Jan 2022 | 223-0 v Salford CitySalford City 0-3 Colchester United | Sky Bet League Two |
| 16 | Sat 29 Jan 2022 | 22 1-1 v Swindon TownColchester United 1-1 Swindon Town | Sky Bet League Two |
| 17 | Tue 1 Feb 2022 | 221-1 v RochdaleColchester United 1-1 Rochdale | Sky Bet League Two |
| 18 | Sat 5 Feb 2022 | 221-0 v Leyton OrientLeyton Orient 0-1 Colchester United | Sky Bet League Two |
| 19 | Tue 8 Feb 2022 | 221-2 v Mansfield TownMansfield Town 2-1 Colchester United | Sky Bet League Two |
| 20 | Sat 12 Feb 2022 | 222-2 v Carlisle UnitedColchester United 2-2 Carlisle United | Sky Bet League Two |
| 21 | Sat 19 Feb 2022 | 220-3 v Northampton TownNorthampton Town 3-0 Colchester United | Sky Bet League Two |
| 22 | Tue 1 Mar 2022 | 222-2 v Leyton OrientColchester United 2-2 Leyton Orient | Sky Bet League Two |
| 23 | Sat 5 Mar 2022 | 221-0 v Port ValeColchester United 1-0 Port Vale | Sky Bet League Two |
| 24 | Mon 21 Mar 2022 | 220-1 v Forest Green RoversColchester United 0-1 Forest Green Rovers | Sky Bet League Two |
| 25 | Sat 26 Mar 2022 | 221-0 v Tranmere RoversColchester United 1-0 Tranmere Rovers | Sky Bet League Two |
| 26 | Sat 2 Apr 2022 | 22 2-1 v Harrogate TownHarrogate Town 1-2 Colchester United | Sky Bet League Two |
| 27 | Mon 18 Apr 2022 | 223-0 v Bradford CityColchester United 3-0 Bradford City | Sky Bet League Two |
| 28 | Fri 22 Apr 2022 | 222-1 v Newport CountyNewport County 1-2 Colchester United | Sky Bet League Two |
| 29 | Sat 30 Apr 2022 | 222-2 v WalsallColchester United 2-2 Walsall | Sky Bet League Two |
| 30 | Sat 7 May 2022 | 222-0 v Hartlepool UnitedHartlepool United 0-2 Colchester United | Sky Bet League Two |
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