| 1 | Tue 18 Jan 2022 | 28 2-3 v Sutton UnitedSutton United 3-2 Colchester United | Sky Bet League Two |
| 2 | Sat 22 Jan 2022 | 28 3-0 v Salford CitySalford City 0-3 Colchester United | Sky Bet League Two |
| 3 | Sat 29 Jan 2022 | 281-1 v Swindon TownColchester United 1-1 Swindon Town | Sky Bet League Two |
| 4 | Tue 1 Feb 2022 | 281-1 v RochdaleColchester United 1-1 Rochdale | Sky Bet League Two |
| 5 | Sat 12 Feb 2022 | 282-2 v Carlisle UnitedColchester United 2-2 Carlisle United | Sky Bet League Two |
| 6 | Sat 19 Feb 2022 | 280-3 v Northampton TownNorthampton Town 3-0 Colchester United | Sky Bet League Two |
| 7 | Tue 1 Mar 2022 | 282-2 v Leyton OrientColchester United 2-2 Leyton Orient | Sky Bet League Two |
| 8 | Sat 5 Mar 2022 | 281-0 v Port ValeColchester United 1-0 Port Vale | Sky Bet League Two |
| 9 | Fri 15 Apr 2022 | 280-2 v Exeter CityExeter City 2-0 Colchester United | Sky Bet League Two |
| 10 | Mon 18 Apr 2022 | 283-0 v Bradford CityColchester United 3-0 Bradford City | Sky Bet League Two |
| 11 | Fri 22 Apr 2022 | 28 2-1 v Newport CountyNewport County 1-2 Colchester United | Sky Bet League Two |
| 12 | Sat 30 Apr 2022 | 282-2 v WalsallColchester United 2-2 Walsall | Sky Bet League Two |
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