| 1 | Sat 8 Aug 2015 | 32-2 v BlackpoolColchester United 2-2 Blackpool | Sky Bet League One |
| 2 | Tue 11 Aug 2015 | 30-1 v ReadingColchester United 0-1 Reading | Capital One Cup First Round |
| 3 | Sat 15 Aug 2015 | 31-2 v Peterborough UnitedPeterborough United 2-1 Colchester United | Sky Bet League One |
| 4 | Sat 29 Aug 2015 | 32-2 v Scunthorpe UnitedColchester United 2-2 Scunthorpe United | Sky Bet League One |
| 5 | Tue 1 Sep 2015 | 32-3 v Northampton TownNorthampton Town 3-2 Colchester United | Johnstone's Paint Trophy Southern Area First Round |
| 6 | Sat 12 Sep 2015 | 33-3 v ChesterfieldChesterfield 3-3 Colchester United | Sky Bet League One |
| 7 | Tue 15 Sep 2015 | 33-2 v Sheffield UnitedSheffield United 2-3 Colchester United | Sky Bet League One |
| 8 | Sat 19 Sep 2015 | 32-1 v GillinghamColchester United 2-1 Gillingham | Sky Bet League One |
| 9 | Sat 26 Sep 2015 | 32-1 v Swindon TownSwindon Town 1-2 Colchester United | Sky Bet League One |
| 10 | Tue 29 Sep 2015 | 32-0 v Bradford CityColchester United 2-0 Bradford City | Sky Bet League One |
| 11 | Sat 3 Oct 2015 | 30-1 v BuryColchester United 0-1 Bury | Sky Bet League One |
| 12 | Sat 17 Oct 2015 | 30-5 v Wigan AthleticWigan Athletic 5-0 Colchester United | Sky Bet League One |
| 13 | Tue 20 Oct 2015 | 32-1 v Port ValeColchester United 2-1 Port Vale | Sky Bet League One |
| 14 | Sat 31 Oct 2015 | 30-2 v Doncaster RoversDoncaster Rovers 2-0 Colchester United | Sky Bet League One |
| 15 | Sat 7 Nov 2015 | 36-2 v WealdstoneWealdstone 2-6 Colchester United | Emirates FA Cup First Round |
| 16 | Sat 14 Nov 2015 | 31-3 v Coventry CityColchester United 1-3 Coventry City | Sky Bet League One |
| 17 | Tue 24 Nov 2015 | 32-3 v Crewe AlexandraColchester United 2-3 Crewe Alexandra | Sky Bet League One |
| 18 | Sat 28 Nov 2015 | 31-5 v Burton AlbionBurton Albion 5-1 Colchester United | Sky Bet League One |
| 19 | Sun 6 Dec 2015 | 33-2 v AltrinchamColchester United 3-2 Altrincham | Emirates FA Cup Second Round |
| 20 | Sat 12 Dec 2015 | 32-3 v BarnsleyColchester United 2-3 Barnsley | Sky Bet League One |
| 21 | Sat 19 Dec 2015 | 31-3 v RochdaleRochdale 3-1 Colchester United | Sky Bet League One |
| 22 | Sat 26 Dec 2015 | 30-2 v Southend UnitedColchester United 0-2 Southend United | Sky Bet League One |
| 23 | Mon 28 Dec 2015 | 30-1 v GillinghamGillingham 1-0 Colchester United | Sky Bet League One |
| 24 | Sat 2 Jan 2016 | 31-1 v Oldham AthleticOldham Athletic 1-1 Colchester United | Sky Bet League One |
| 25 | Sat 9 Jan 2016 | 32-1 v Charlton AthleticColchester United 2-1 Charlton Athletic | Emirates FA Cup Third Round |
| 26 | Sat 16 Jan 2016 | 31-2 v Sheffield UnitedColchester United 1-2 Sheffield United | Sky Bet League One |
| 27 | Tue 19 Jan 2016 | 31-1 v Fleetwood TownColchester United 1-1 Fleetwood Town | Sky Bet League One |
| 28 | Sat 23 Jan 2016 | 30-3 v Scunthorpe UnitedScunthorpe United 3-0 Colchester United | Sky Bet League One |
| 29 | Sat 30 Jan 2016 | 31-4 v Tottenham HotspurColchester United 1-4 Tottenham Hotspur | Emirates FA Cup Fourth Round |
| 30 | Sat 6 Feb 2016 | 30-3 v Southend UnitedSouthend United 3-0 Colchester United | Sky Bet League One |
| 31 | Sat 12 Mar 2016 | 33-3 v Wigan AthleticColchester United 3-3 Wigan Athletic | Sky Bet League One |
| 32 | Sun 8 May 2016 | 31-2 v RochdaleColchester United 1-2 Rochdale | Sky Bet League One |
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