| 1 | Sun 6 Feb 2022 | 71-2 v KAA GentClub Brugge 1-2 KAA Gent | Belgian First Division A |
| 2 | Sun 13 Feb 2022 | 72-0 v Sporting de CharleroiClub Brugge 2-0 Sporting de Charleroi | Belgian First Division A |
| 3 | Sun 20 Feb 2022 | 73-1 v KAS EupenKAS Eupen 1-3 Club Brugge | Belgian First Division A |
| 4 | Sun 27 Feb 2022 | 74-1 v Royal AntwerpClub Brugge 4-1 Royal Antwerp | Belgian First Division A |
| 5 | Sat 5 Mar 2022 | 75-0 v SeraingSeraing 0-5 Club Brugge | Belgian First Division A |
| 6 | Sat 12 Mar 2022 | 73-1 v KV OostendeKV Oostende 1-3 Club Brugge | Belgian First Division A |
| 7 | Sun 20 Mar 2022 | 73-1 v KRC GenkClub Brugge 3-1 KRC Genk | Belgian First Division A |
| 8 | Fri 1 Apr 2022 | 73-1 v Germinal BeerschotGerminal Beerschot 1-3 Club Brugge | Belgian First Division A |
| 9 | Sun 10 Apr 2022 | 72-0 v MechelenClub Brugge 2-0 Mechelen | Belgian First Division A |
| 10 | Sun 24 Apr 2022 | 71-0 v Royal AntwerpClub Brugge 1-0 Royal Antwerp | Belgian First Division A Play-off |
| 11 | Sun 1 May 2022 | 70-0 v RSC AnderlechtRSC Anderlecht 0-0 Club Brugge | Belgian First Division A Play-off |
| 12 | Sun 8 May 2022 | 72-0 v Union Saint-GilloiseUnion Saint-Gilloise 0-2 Club Brugge | Belgian First Division A Play-off |
| 13 | Wed 11 May 2022 | 71-0 v Union Saint-GilloiseClub Brugge 1-0 Union Saint-Gilloise | Belgian First Division A Play-off |
| 14 | Sun 15 May 2022 | 73-1 v Royal AntwerpRoyal Antwerp 1-3 Club Brugge | Belgian First Division A Play-off |
| 15 | Sun 22 May 2022 | 71-1 v RSC AnderlechtClub Brugge 1-1 RSC Anderlecht | Belgian First Division A Play-off |
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