| 1 | Sat 9 Aug | 242-1 v WrexhamSouthampton 2-1 Wrexham |
| 2 | Sun 17 Aug | 24 1-1 v Ipswich TownIpswich Town 1-1 Southampton |
| 3 | Sat 23 Aug | 241-2 v Stoke CitySouthampton 1-2 Stoke City |
| 4 | Sat 30 Aug | 24 2-2 v WatfordWatford 2-2 Southampton |
| 5 | Sun 14 Sep | 240-0 v PortsmouthSouthampton 0-0 Portsmouth |
| 6 | Sat 20 Sep | 241-3 v Hull CityHull City 3-1 Southampton |
| 7 | Sat 27 Sep | 241-1 v MiddlesbroughSouthampton 1-1 Middlesbrough |
| 8 | Tue 30 Sep | 24 2-1 v Sheffield UnitedSheffield United 1-2 Southampton |
| 9 | Sat 4 Oct | 241-1 v Derby CountyDerby County 1-1 Southampton |
| 10 | Sat 18 Oct | 240-0 v Swansea CitySouthampton 0-0 Swansea City |
| 11 | Tue 21 Oct | 241-3 v Bristol CityBristol City 3-1 Southampton |
| 12 | Sat 25 Oct | 241-2 v Blackburn RoversBlackburn Rovers 2-1 Southampton |
| 13 | Wed 21 Jan | 24 1-0 v Sheffield UnitedSouthampton 1-0 Sheffield United |
| 14 | Sun 25 Jan | 241-1 v PortsmouthPortsmouth 1-1 Southampton |
| 15 | Sat 31 Jan | 242-0 v Stoke CityStoke City 0-2 Southampton |
| 16 | Sat 7 Feb | 24 1-0 v WatfordSouthampton 1-0 Watford |
| 17 | Tue 10 Feb | 244-3 v Leicester CityLeicester City 3-4 Southampton |
| 18 | Sat 21 Feb | 241-1 v Charlton AthleticSouthampton 1-1 Charlton Athletic |
| 19 | Tue 24 Feb | 245-0 v Queens Park RangersSouthampton 5-0 Queens Park Rangers |
| 20 | Sat 28 Feb | 243-1 v Sheffield WednesdaySheffield Wednesday 1-3 Southampton |
| 21 | Wed 11 Mar | 241-1 v West Bromwich AlbionWest Bromwich Albion 1-1 Southampton |
| 22 | Sat 14 Mar | 242-1 v Coventry CityCoventry City 1-2 Southampton |
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