| 1 | Sat 9 Aug | 4 2-1 v WrexhamSouthampton 2-1 Wrexham |
| 2 | Sun 17 Aug | 41-1 v Ipswich TownIpswich Town 1-1 Southampton |
| 3 | Sat 23 Aug | 41-2 v Stoke CitySouthampton 1-2 Stoke City |
| 4 | Sun 14 Sep | 4 0-0 v PortsmouthSouthampton 0-0 Portsmouth |
| 5 | Tue 30 Sep | 42-1 v Sheffield UnitedSheffield United 1-2 Southampton |
| 6 | Sat 4 Oct | 4 1-1 v Derby CountyDerby County 1-1 Southampton |
| 7 | Tue 21 Oct | 41-3 v Bristol CityBristol City 3-1 Southampton |
| 8 | Sat 1 Nov | 40-2 v Preston North EndSouthampton 0-2 Preston North End |
| 9 | Wed 5 Nov | 4 2-1 v Queens Park RangersQueens Park Rangers 1-2 Southampton |
| 10 | Sat 8 Nov | 43-1 v Sheffield WednesdaySouthampton 3-1 Sheffield Wednesday |
| 11 | Sat 22 Nov | 45-1 v Charlton AthleticCharlton Athletic 1-5 Southampton |
| 12 | Tue 25 Nov | 4 3-0 v Leicester CitySouthampton 3-0 Leicester City |
| 13 | Sat 6 Dec | 43-1 v Birmingham CitySouthampton 3-1 Birmingham City |
| 14 | Tue 9 Dec | 43-2 v West Bromwich AlbionSouthampton 3-2 West Bromwich Albion |
| 15 | Sat 13 Dec | 4 1-2 v Norwich CityNorwich City 2-1 Southampton |
| 16 | Sat 20 Dec | 41-1 v Coventry CitySouthampton 1-1 Coventry City |
| 17 | Fri 26 Dec | 4 1-2 v Oxford UnitedOxford United 2-1 Southampton |
| 18 | Mon 29 Dec | 41-1 v Birmingham CityBirmingham City 1-1 Southampton |
| 19 | Thu 1 Jan | 40-0 v MillwallSouthampton 0-0 Millwall |
| 20 | Sun 4 Jan | 40-4 v MiddlesbroughMiddlesbrough 4-0 Southampton |
| 21 | Sat 17 Jan | 41-2 v Hull CitySouthampton 1-2 Hull City |
| 22 | Wed 21 Jan | 41-0 v Sheffield UnitedSouthampton 1-0 Sheffield United |
| 23 | Sun 25 Jan | 4 1-1 v PortsmouthPortsmouth 1-1 Southampton |
| 24 | Sat 31 Jan | 42-0 v Stoke CityStoke City 0-2 Southampton |
| 25 | Sat 7 Feb | 41-0 v WatfordSouthampton 1-0 Watford |
| 26 | Tue 10 Feb | 44-3 v Leicester CityLeicester City 3-4 Southampton |
| 27 | Sat 21 Feb | 4 1-1 v Charlton AthleticSouthampton 1-1 Charlton Athletic |
| 28 | Tue 24 Feb | 45-0 v Queens Park RangersSouthampton 5-0 Queens Park Rangers |
| 29 | Wed 11 Mar | 41-1 v West Bromwich AlbionWest Bromwich Albion 1-1 Southampton |
| 30 | Sat 14 Mar | 42-1 v Coventry CityCoventry City 1-2 Southampton |