| 1 | Sat 29 Jan 2022 | 60-2 v Sutton UnitedCarlisle United 0-2 Sutton United | Sky Bet League Two |
| 2 | Tue 1 Feb 2022 | 61-2 v Salford CitySalford City 2-1 Carlisle United | Sky Bet League Two |
| 3 | Tue 8 Feb 2022 | 61-3 v Port ValeCarlisle United 1-3 Port Vale | Sky Bet League Two |
| 4 | Sat 12 Feb 2022 | 62-2 v Colchester UnitedColchester United 2-2 Carlisle United | Sky Bet League Two |
| 5 | Sat 19 Feb 2022 | 6 0-3 v Swindon TownCarlisle United 0-3 Swindon Town | Sky Bet League Two |
| 6 | Sat 26 Feb 2022 | 6 1-0 v Leyton OrientLeyton Orient 0-1 Carlisle United | Sky Bet League Two |
| 7 | Tue 1 Mar 2022 | 62-0 v RochdaleCarlisle United 2-0 Rochdale | Sky Bet League Two |
| 8 | Sat 5 Mar 2022 | 6 2-1 v Oldham AthleticOldham Athletic 1-2 Carlisle United | Sky Bet League Two |
| 9 | Sat 12 Mar 2022 | 62-1 v Northampton TownCarlisle United 2-1 Northampton Town | Sky Bet League Two |
| 10 | Tue 15 Mar 2022 | 61-2 v Newport CountyCarlisle United 1-2 Newport County | Sky Bet League Two |
| 11 | Sat 19 Mar 2022 | 62-1 v BarrowBarrow 1-2 Carlisle United | Sky Bet League Two |
| 12 | Sat 26 Mar 2022 | 61-0 v Bristol RoversCarlisle United 1-0 Bristol Rovers | Sky Bet League Two |
| 13 | Tue 29 Mar 2022 | 6 0-2 v RochdaleRochdale 2-0 Carlisle United | Sky Bet League Two |
| 14 | Sat 2 Apr 2022 | 6 2-2 v Tranmere RoversTranmere Rovers 2-2 Carlisle United | Sky Bet League Two |
| 15 | Sat 9 Apr 2022 | 6 0-1 v Exeter CityCarlisle United 0-1 Exeter City | Sky Bet League Two |
| 16 | Fri 15 Apr 2022 | 6 0-1 v WalsallWalsall 1-0 Carlisle United | Sky Bet League Two |
| 17 | Mon 18 Apr 2022 | 6 1-0 v Mansfield TownCarlisle United 1-0 Mansfield Town | Sky Bet League Two |
| 18 | Sat 23 Apr 2022 | 60-3 v Harrogate TownHarrogate Town 3-0 Carlisle United | Sky Bet League Two |
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