| 1 | Sat 7 Aug 2021 | 110-0 v Colchester UnitedCarlisle United 0-0 Colchester United | Sky Bet League Two |
| 2 | Sat 14 Aug 2021 | 11 2-1 v Swindon TownSwindon Town 1-2 Carlisle United | Sky Bet League Two |
| 3 | Tue 17 Aug 2021 | 11 0-0 v Port ValePort Vale 0-0 Carlisle United | Sky Bet League Two |
| 4 | Sat 21 Aug 2021 | 111-1 v Leyton OrientCarlisle United 1-1 Leyton Orient | Sky Bet League Two |
| 5 | Sat 28 Aug 2021 | 111-2 v Hartlepool UnitedHartlepool United 2-1 Carlisle United | Sky Bet League Two |
| 6 | Tue 31 Aug 2021 | 113-3 v Hartlepool UnitedCarlisle United 3-3 Hartlepool United | Papa John’s Trophy |
| 7 | Sat 4 Sep 2021 | 112-1 v Salford CityCarlisle United 2-1 Salford City | Sky Bet League Two |
| 8 | Sat 11 Sep 2021 | 111-2 v Crawley TownCrawley Town 2-1 Carlisle United | Sky Bet League Two |
| 9 | Sat 18 Sep 2021 | 112-2 v Scunthorpe UnitedCarlisle United 2-2 Scunthorpe United | Sky Bet League Two |
| 10 | Sat 25 Sep 2021 | 11 0-4 v Sutton UnitedSutton United 4-0 Carlisle United | Sky Bet League Two |
| 11 | Sat 2 Oct 2021 | 11 0-2 v Forest Green RoversCarlisle United 0-2 Forest Green Rovers | Sky Bet League Two |
| 12 | Sat 9 Oct 2021 | 110-3 v Bristol RoversBristol Rovers 3-0 Carlisle United | Sky Bet League Two |
| 13 | Sat 16 Oct 2021 | 110-1 v Tranmere RoversCarlisle United 0-1 Tranmere Rovers | Sky Bet League Two |
| 14 | Tue 19 Oct 2021 | 112-2 v Newport CountyNewport County 2-2 Carlisle United | Sky Bet League Two |
| 15 | Sat 23 Oct 2021 | 110-0 v Oldham AthleticCarlisle United 0-0 Oldham Athletic | Sky Bet League Two |
| 16 | Sat 30 Oct 2021 | 110-3 v Northampton TownNorthampton Town 3-0 Carlisle United | Sky Bet League Two |
| 17 | Sat 13 Nov 2021 | 110-0 v BarrowCarlisle United 0-0 Barrow | Sky Bet League Two |
| 18 | Sat 20 Nov 2021 | 111-2 v Exeter CityExeter City 2-1 Carlisle United | Sky Bet League Two |
| 19 | Tue 23 Nov 2021 | 110-2 v Harrogate TownCarlisle United 0-2 Harrogate Town | Sky Bet League Two |
| 20 | Sat 4 Dec 2021 | 111-2 v Shrewsbury TownCarlisle United 1-2 Shrewsbury Town | Emirates FA Cup Second Round |
| 21 | Tue 7 Dec 2021 | 110-1 v Mansfield TownMansfield Town 1-0 Carlisle United | Sky Bet League Two |
| 22 | Sat 11 Dec 2021 | 112-0 v StevenageStevenage 0-2 Carlisle United | Sky Bet League Two |
| 23 | Sat 1 Jan 2022 | 11 1-0 v Scunthorpe UnitedScunthorpe United 0-1 Carlisle United | Sky Bet League Two |
| 24 | Tue 4 Jan 2022 | 11 0-1 v Harrogate TownHarrogate Town 1-0 Carlisle United | Papa John’s Trophy Third Round |
| 25 | Sat 8 Jan 2022 | 112-0 v Bradford CityCarlisle United 2-0 Bradford City | Sky Bet League Two |
| 26 | Sat 15 Jan 2022 | 111-1 v Crawley TownCarlisle United 1-1 Crawley Town | Sky Bet League Two |
| 27 | Tue 18 Jan 2022 | 110-0 v Hartlepool UnitedCarlisle United 0-0 Hartlepool United | Sky Bet League Two |
| 28 | Sat 22 Jan 2022 | 110-3 v Forest Green RoversForest Green Rovers 3-0 Carlisle United | Sky Bet League Two |
| 29 | Sat 29 Jan 2022 | 110-2 v Sutton UnitedCarlisle United 0-2 Sutton United | Sky Bet League Two |
| 30 | Tue 1 Feb 2022 | 111-2 v Salford CitySalford City 2-1 Carlisle United | Sky Bet League Two |
| 31 | Sat 12 Mar 2022 | 112-1 v Northampton TownCarlisle United 2-1 Northampton Town | Sky Bet League Two |
| 32 | Tue 15 Mar 2022 | 111-2 v Newport CountyCarlisle United 1-2 Newport County | Sky Bet League Two |
| 33 | Sat 19 Mar 2022 | 11 2-1 v BarrowBarrow 1-2 Carlisle United | Sky Bet League Two |
| 34 | Sat 26 Mar 2022 | 11 1-0 v Bristol RoversCarlisle United 1-0 Bristol Rovers | Sky Bet League Two |
| 35 | Tue 29 Mar 2022 | 11 0-2 v RochdaleRochdale 2-0 Carlisle United | Sky Bet League Two |
| 36 | Sat 2 Apr 2022 | 112-2 v Tranmere RoversTranmere Rovers 2-2 Carlisle United | Sky Bet League Two |
| 37 | Sat 9 Apr 2022 | 11 0-1 v Exeter CityCarlisle United 0-1 Exeter City | Sky Bet League Two |
| 38 | Fri 15 Apr 2022 | 110-1 v WalsallWalsall 1-0 Carlisle United | Sky Bet League Two |
| 39 | Mon 18 Apr 2022 | 11 1-0 v Mansfield TownCarlisle United 1-0 Mansfield Town | Sky Bet League Two |
| 40 | Sat 23 Apr 2022 | 110-3 v Harrogate TownHarrogate Town 3-0 Carlisle United | Sky Bet League Two |
| 41 | Sat 30 Apr 2022 | 112-1 v StevenageCarlisle United 2-1 Stevenage | Sky Bet League Two |
| 42 | Sat 7 May 2022 | 11 0-2 v Bradford CityBradford City 2-0 Carlisle United | Sky Bet League Two |