| 1 | Sat 7 Aug 2021 | 61-1 v Oxford UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | Tue 10 Aug 2021 | 60-0 v Swindon TownCambridge United 0-0 Swindon Town | Carabao Cup First Round |
| 3 | Tue 17 Aug 2021 | 61-1 v Plymouth ArgylePlymouth Argyle 1-1 Cambridge United | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 6 3-0 v Burton AlbionCambridge United 3-0 Burton Albion | Sky Bet League One |
| 5 | Tue 24 Aug 2021 | 61-3 v MillwallMillwall 3-1 Cambridge United | Carabao Cup Second Round |
| 6 | Sat 28 Aug 2021 | 61-0 v Bolton WanderersCambridge United 1-0 Bolton Wanderers | Sky Bet League One |
| 7 | Sat 11 Sep 2021 | 61-5 v Lincoln CityCambridge United 1-5 Lincoln City | Sky Bet League One |
| 8 | Sat 18 Sep 2021 | 62-1 v PortsmouthPortsmouth 1-2 Cambridge United | Sky Bet League One |
| 9 | Tue 28 Sep 2021 | 6 0-2 v GillinghamCambridge United 0-2 Gillingham | Sky Bet League One |
| 10 | Sat 2 Oct 2021 | 62-2 v Crewe AlexandraCrewe Alexandra 2-2 Cambridge United | Sky Bet League One |
| 11 | Sat 16 Oct 2021 | 62-2 v Ipswich TownCambridge United 2-2 Ipswich Town | Sky Bet League One |
| 12 | Tue 19 Oct 2021 | 61-1 v Sheffield WednesdayCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 13 | Sat 23 Oct 2021 | 6 1-4 v Shrewsbury TownShrewsbury Town 4-1 Cambridge United | Sky Bet League One |
| 14 | Tue 26 Oct 2021 | 61-1 v Doncaster RoversDoncaster Rovers 1-1 Cambridge United | Sky Bet League One |
| 15 | Sat 30 Oct 2021 | 6 1-0 v AFC WimbledonCambridge United 1-0 AFC Wimbledon | Sky Bet League One |
| 16 | Tue 1 Mar 2022 | 60-3 v Wycombe WanderersWycombe Wanderers 3-0 Cambridge United | Sky Bet League One |
| 17 | Sat 5 Mar 2022 | 60-0 v Shrewsbury TownCambridge United 0-0 Shrewsbury Town | Sky Bet League One |
| 18 | Sat 12 Mar 2022 | 60-6 v Sheffield WednesdaySheffield Wednesday 6-0 Cambridge United | Sky Bet League One |
| 19 | Sat 19 Mar 2022 | 60-1 v Milton Keynes DonsCambridge United 0-1 Milton Keynes Dons | Sky Bet League One |
| 20 | Sat 26 Mar 2022 | 61-0 v AFC WimbledonAFC Wimbledon 0-1 Cambridge United | Sky Bet League One |
| 21 | Sat 2 Apr 2022 | 61-0 v Ipswich TownIpswich Town 0-1 Cambridge United | Sky Bet League One |
| 22 | Tue 5 Apr 2022 | 61-4 v Wycombe WanderersCambridge United 1-4 Wycombe Wanderers | Sky Bet League One |
| 23 | Sat 9 Apr 2022 | 62-1 v MorecambeCambridge United 2-1 Morecambe | Sky Bet League One |
| 24 | Sat 16 Apr 2022 | 62-1 v Wigan AthleticWigan Athletic 1-2 Cambridge United | Sky Bet League One |
| 25 | Tue 19 Apr 2022 | 60-2 v Charlton AthleticCambridge United 0-2 Charlton Athletic | Sky Bet League One |
| 26 | Sat 23 Apr 2022 | 6 1-5 v SunderlandSunderland 5-1 Cambridge United | Sky Bet League One |
| 27 | Sat 30 Apr 2022 | 62-2 v Cheltenham TownCambridge United 2-2 Cheltenham Town | Sky Bet League One |
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