| 1 | Tue 24 Aug 2021 | 231-3 v MillwallMillwall 3-1 Cambridge United | Carabao Cup Second Round |
| 2 | Tue 31 Aug 2021 | 234-1 v Oxford UnitedCambridge United 4-1 Oxford United | Papa John’s Trophy |
| 3 | Sat 11 Sep 2021 | 231-5 v Lincoln CityCambridge United 1-5 Lincoln City | Sky Bet League One |
| 4 | Tue 28 Sep 2021 | 230-2 v GillinghamCambridge United 0-2 Gillingham | Sky Bet League One |
| 5 | Sat 2 Oct 2021 | 232-2 v Crewe AlexandraCrewe Alexandra 2-2 Cambridge United | Sky Bet League One |
| 6 | Tue 16 Nov 2021 | 233-1 v Northampton TownCambridge United 3-1 Northampton Town | Emirates FA Cup First Round Replay |
| 7 | Tue 7 Dec 2021 | 235-0 v Cheltenham TownCheltenham Town 0-5 Cambridge United | Sky Bet League One |
| 8 | Sat 11 Dec 2021 | 230-2 v Charlton AthleticCharlton Athletic 2-0 Cambridge United | Sky Bet League One |
| 9 | Sat 18 Dec 2021 | 230-1 v Rotherham UnitedCambridge United 0-1 Rotherham United | Sky Bet League One |
| 10 | Sat 8 Jan 2022 | 23 1-0 v Newcastle UnitedNewcastle United 0-1 Cambridge United | Emirates FA Cup Third Round |
| 11 | Tue 11 Jan 2022 | 23 2-1 v PortsmouthCambridge United 2-1 Portsmouth | Papa John’s Trophy Third Round |
| 12 | Sat 15 Jan 2022 | 231-0 v Lincoln CityLincoln City 0-1 Cambridge United | Sky Bet League One |
| 13 | Tue 18 Jan 2022 | 233-1 v Doncaster RoversCambridge United 3-1 Doncaster Rovers | Sky Bet League One |
| 14 | Sat 22 Jan 2022 | 231-0 v Crewe AlexandraCambridge United 1-0 Crewe Alexandra | Sky Bet League One |
| 15 | Sat 29 Jan 2022 | 231-1 v Fleetwood TownFleetwood Town 1-1 Cambridge United | Sky Bet League One |
| 16 | Tue 1 Feb 2022 | 230-2 v Bolton WanderersBolton Wanderers 2-0 Cambridge United | Sky Bet League One |
| 17 | Sat 5 Feb 2022 | 230-3 v Luton TownCambridge United 0-3 Luton Town | Emirates FA Cup Fourth Round |
| 18 | Tue 8 Feb 2022 | 230-1 v GillinghamGillingham 1-0 Cambridge United | Sky Bet League One |
| 19 | Tue 22 Feb 2022 | 232-0 v Plymouth ArgyleCambridge United 2-0 Plymouth Argyle | Sky Bet League One |
| 20 | Sat 26 Feb 2022 | 232-4 v Oxford UnitedOxford United 4-2 Cambridge United | Sky Bet League One |
| 21 | Tue 1 Mar 2022 | 230-3 v Wycombe WanderersWycombe Wanderers 3-0 Cambridge United | Sky Bet League One |
| 22 | Sat 19 Mar 2022 | 230-1 v Milton Keynes DonsCambridge United 0-1 Milton Keynes Dons | Sky Bet League One |
| 23 | Tue 5 Apr 2022 | 231-4 v Wycombe WanderersCambridge United 1-4 Wycombe Wanderers | Sky Bet League One |
| 24 | Tue 19 Apr 2022 | 230-2 v Charlton AthleticCambridge United 0-2 Charlton Athletic | Sky Bet League One |
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