| 1 | Fri 13 Aug 2021 | 62-0 v ArsenalBrentford 2-0 Arsenal | Premier League |
| 2 | Sat 21 Aug 2021 | 6 0-0 v Crystal PalaceCrystal Palace 0-0 Brentford | Premier League |
| 3 | Sat 28 Aug 2021 | 6 1-1 v Aston VillaAston Villa 1-1 Brentford | Premier League |
| 4 | Sat 11 Sep 2021 | 60-1 v Brighton & Hove AlbionBrentford 0-1 Brighton & Hove Albion | Premier League |
| 5 | Sat 18 Sep 2021 | 62-0 v Wolverhampton WanderersWolverhampton Wanderers 0-2 Brentford | Premier League |
| 6 | Sat 25 Sep 2021 | 63-3 v LiverpoolBrentford 3-3 Liverpool | Premier League |
| 7 | Sun 3 Oct 2021 | 6 2-1 v West Ham UnitedWest Ham United 1-2 Brentford | Premier League |
| 8 | Sat 16 Oct 2021 | 60-1 v ChelseaBrentford 0-1 Chelsea | Premier League |
| 9 | Sun 24 Oct 2021 | 61-2 v Leicester CityBrentford 1-2 Leicester City | Premier League |
| 10 | Wed 27 Oct 2021 | 62-1 v Stoke CityStoke City 1-2 Brentford | Carabao Cup Round of 16 |
| 11 | Sat 30 Oct 2021 | 61-3 v BurnleyBurnley 3-1 Brentford | Premier League |
| 12 | Sat 6 Nov 2021 | 61-2 v Norwich CityBrentford 1-2 Norwich City | Premier League |
| 13 | Sat 20 Nov 2021 | 6 3-3 v Newcastle UnitedNewcastle United 3-3 Brentford | Premier League |
| 14 | Sun 28 Nov 2021 | 61-0 v EvertonBrentford 1-0 Everton | Premier League |
| 15 | Thu 2 Dec 2021 | 60-2 v Tottenham HotspurTottenham Hotspur 2-0 Brentford | Premier League |
| 16 | Sun 5 Dec 2021 | 62-2 v Leeds UnitedLeeds United 2-2 Brentford | Premier League |
| 17 | Fri 10 Dec 2021 | 62-1 v WatfordBrentford 2-1 Watford | Premier League |
| 18 | Wed 22 Dec 2021 | 60-2 v ChelseaBrentford 0-2 Chelsea | Carabao Cup Quarter Final |
| 19 | Sun 26 Dec 2021 | 6 0-2 v Brighton & Hove AlbionBrighton & Hove Albion 2-0 Brentford | Premier League |
| 20 | Sun 2 Jan 2022 | 62-1 v Aston VillaBrentford 2-1 Aston Villa | Premier League |
| 21 | Tue 11 Jan 2022 | 61-4 v SouthamptonSouthampton 4-1 Brentford | Premier League |
| 22 | Sun 16 Jan 2022 | 60-3 v LiverpoolLiverpool 3-0 Brentford | Premier League |
| 23 | Wed 19 Jan 2022 | 61-3 v Manchester UnitedBrentford 1-3 Manchester United | Premier League |
| 24 | Sat 22 Jan 2022 | 6 1-2 v Wolverhampton WanderersBrentford 1-2 Wolverhampton Wanderers | Premier League |
| 25 | Sat 5 Feb 2022 | 61-4 v EvertonEverton 4-1 Brentford | Emirates FA Cup Fourth Round |
| 26 | Wed 9 Feb 2022 | 60-2 v Manchester CityManchester City 2-0 Brentford | Premier League |
| 27 | Sat 12 Feb 2022 | 60-0 v Crystal PalaceBrentford 0-0 Crystal Palace | Premier League |
| 28 | Sat 19 Feb 2022 | 61-2 v ArsenalArsenal 2-1 Brentford | Premier League |
| 29 | Sat 26 Feb 2022 | 60-2 v Newcastle UnitedBrentford 0-2 Newcastle United | Premier League |
| 30 | Sat 5 Mar 2022 | 63-1 v Norwich CityNorwich City 1-3 Brentford | Premier League |
| 31 | Sat 12 Mar 2022 | 62-0 v BurnleyBrentford 2-0 Burnley | Premier League |
| 32 | Sun 20 Mar 2022 | 6 1-2 v Leicester CityLeicester City 2-1 Brentford | Premier League |
| 33 | Sat 2 Apr 2022 | 64-1 v ChelseaChelsea 1-4 Brentford | Premier League |
| 34 | Sun 10 Apr 2022 | 62-0 v West Ham UnitedBrentford 2-0 West Ham United | Premier League |
| 35 | Sat 16 Apr 2022 | 62-1 v WatfordWatford 1-2 Brentford | Premier League |
| 36 | Mon 2 May 2022 | 60-3 v Manchester UnitedManchester United 3-0 Brentford | Premier League |
| 37 | Sat 7 May 2022 | 63-0 v SouthamptonBrentford 3-0 Southampton | Premier League |
| 38 | Sun 15 May 2022 | 63-2 v EvertonEverton 2-3 Brentford | Premier League |
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