| 1 | Sat 24 Aug | 52-0 v Eintracht FrankfurtBorussia Dortmund 2-0 Eintracht Frankfurt | German Bundesliga |
| 2 | Sat 31 Aug | 5 0-0 v Werder BremenWerder Bremen 0-0 Borussia Dortmund | German Bundesliga |
| 3 | Fri 13 Sep | 54-2 v 1 FC HeidenheimBorussia Dortmund 4-2 1 FC Heidenheim | German Bundesliga |
| 4 | Wed 18 Sep | 53-0 v Club BruggeClub Brugge 0-3 Borussia Dortmund | UEFA Champions League Matchday 1 |
| 5 | Sun 22 Sep | 5 1-5 v VfB StuttgartVfB Stuttgart 5-1 Borussia Dortmund | German Bundesliga |
| 6 | Fri 27 Sep | 54-2 v VfL BochumBorussia Dortmund 4-2 VfL Bochum | German Bundesliga |
| 7 | Tue 1 Oct | 5 7-1 v CelticBorussia Dortmund 7-1 Celtic | UEFA Champions League Matchday 2 |
| 8 | Sat 5 Oct | 5 1-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 Borussia Dortmund | German Bundesliga |
| 9 | Fri 18 Oct | 52-1 v FC St PauliBorussia Dortmund 2-1 FC St Pauli | German Bundesliga |
| 10 | Tue 22 Oct | 52-5 v Real MadridReal Madrid 5-2 Borussia Dortmund | UEFA Champions League Matchday 3 |
| 11 | Sat 26 Oct | 5 1-2 v FC AugsburgFC Augsburg 2-1 Borussia Dortmund | German Bundesliga |
| 12 | Sat 2 Nov | 5 2-1 v RB LeipzigBorussia Dortmund 2-1 RB Leipzig | German Bundesliga |
| 13 | Tue 5 Nov | 51-0 v Sturm GrazBorussia Dortmund 1-0 Sturm Graz | UEFA Champions League Matchday 4 |
| 14 | Sat 23 Nov | 54-0 v SC FreiburgBorussia Dortmund 4-0 SC Freiburg | German Bundesliga |
| 15 | Wed 27 Nov | 5 3-0 v Dinamo ZagrebDinamo Zagreb 0-3 Borussia Dortmund | UEFA Champions League Matchday 5 |
| 16 | Sat 30 Nov | 51-1 v Bayern MunichBorussia Dortmund 1-1 Bayern Munich | German Bundesliga |
| 17 | Sat 7 Dec | 51-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 Borussia Dortmund | German Bundesliga |
| 18 | Wed 11 Dec | 5 2-3 v BarcelonaBorussia Dortmund 2-3 Barcelona | UEFA Champions League Matchday 6 |
| 19 | Sun 15 Dec | 51-1 v 1899 HoffenheimBorussia Dortmund 1-1 1899 Hoffenheim | German Bundesliga |
| 20 | Sun 22 Dec | 53-1 v VfL WolfsburgVfL Wolfsburg 1-3 Borussia Dortmund | German Bundesliga |
| 21 | Tue 14 Jan | 52-4 v Holstein KielHolstein Kiel 4-2 Borussia Dortmund | German Bundesliga |
| 22 | Fri 17 Jan | 50-2 v Eintracht FrankfurtEintracht Frankfurt 2-0 Borussia Dortmund | German Bundesliga |
| 23 | Sat 25 Jan | 52-2 v Werder BremenBorussia Dortmund 2-2 Werder Bremen | German Bundesliga |
| 24 | Wed 29 Jan | 53-1 v Shakhtar DonetskBorussia Dortmund 3-1 Shakhtar Donetsk | UEFA Champions League Matchday 8 |
| 25 | Sat 1 Feb | 52-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 Borussia Dortmund | German Bundesliga |
| 26 | Sat 8 Feb | 51-2 v VfB StuttgartBorussia Dortmund 1-2 VfB Stuttgart | German Bundesliga |
| 27 | Wed 19 Feb | 50-0 v Sporting CPBorussia Dortmund 0-0 Sporting CP | UEFA Champions League Play-off Knockout Round |
| 28 | Sat 22 Feb | 5 6-0 v 1 FC Union BerlinBorussia Dortmund 6-0 1 FC Union Berlin | German Bundesliga |
| 29 | Sat 1 Mar | 52-0 v FC St PauliFC St Pauli 0-2 Borussia Dortmund | German Bundesliga |
| 30 | Tue 4 Mar | 51-1 v LilleBorussia Dortmund 1-1 Lille | UEFA Champions League Round of 16 |
| 31 | Sat 8 Mar | 50-1 v FC AugsburgBorussia Dortmund 0-1 FC Augsburg | German Bundesliga |
| 32 | Wed 12 Mar | 5 2-1 v LilleLille 1-2 Borussia Dortmund | UEFA Champions League Round of 16 |
| 33 | Sat 15 Mar | 50-2 v RB LeipzigRB Leipzig 2-0 Borussia Dortmund | German Bundesliga |
| 34 | Sun 30 Mar | 53-1 v Mainz 05Borussia Dortmund 3-1 Mainz 05 | German Bundesliga |
| 35 | Sat 5 Apr | 54-1 v SC FreiburgSC Freiburg 1-4 Borussia Dortmund | German Bundesliga |
| 36 | Wed 9 Apr | 50-4 v BarcelonaBarcelona 4-0 Borussia Dortmund | UEFA Champions League Quarter Final |
| 37 | Sat 12 Apr | 52-2 v Bayern MunichBayern Munich 2-2 Borussia Dortmund | German Bundesliga |
| 38 | Tue 15 Apr | 53-1 v BarcelonaBorussia Dortmund 3-1 Barcelona | UEFA Champions League Quarter Final |
| 39 | Sun 20 Apr | 53-2 v Borussia MönchengladbachBorussia Dortmund 3-2 Borussia Mönchengladbach | German Bundesliga |
| 40 | Sat 26 Apr | 53-2 v 1899 Hoffenheim1899 Hoffenheim 2-3 Borussia Dortmund | German Bundesliga |
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