| 1 | Sat 6 Aug 2022 | 4 1-0 v Bayer 04 LeverkusenBorussia Dortmund 1-0 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Fri 12 Aug 2022 | 4 3-1 v SC FreiburgSC Freiburg 1-3 Borussia Dortmund | German Bundesliga |
| 3 | Sat 20 Aug 2022 | 42-3 v Werder BremenBorussia Dortmund 2-3 Werder Bremen | German Bundesliga |
| 4 | Sat 27 Aug 2022 | 41-0 v Hertha BerlinHertha Berlin 0-1 Borussia Dortmund | German Bundesliga |
| 5 | Fri 2 Sep 2022 | 41-0 v 1899 HoffenheimBorussia Dortmund 1-0 1899 Hoffenheim | German Bundesliga |
| 6 | Tue 6 Sep 2022 | 43-0 v FC CopenhagenBorussia Dortmund 3-0 FC Copenhagen | UEFA Champions League Group G |
| 7 | Sat 10 Sep 2022 | 40-3 v RB LeipzigRB Leipzig 3-0 Borussia Dortmund | German Bundesliga |
| 8 | Wed 14 Sep 2022 | 41-2 v Manchester CityManchester City 2-1 Borussia Dortmund | UEFA Champions League Group G |
| 9 | Sat 17 Sep 2022 | 41-0 v FC Schalke 04Borussia Dortmund 1-0 FC Schalke 04 | German Bundesliga |
| 10 | Sat 1 Oct 2022 | 42-3 v 1 FC Köln1 FC Köln 3-2 Borussia Dortmund | German Bundesliga |
| 11 | Wed 5 Oct 2022 | 44-1 v SevillaSevilla 1-4 Borussia Dortmund | UEFA Champions League Group G |
| 12 | Sat 8 Oct 2022 | 42-2 v Bayern MunichBorussia Dortmund 2-2 Bayern Munich | German Bundesliga |
| 13 | Tue 11 Oct 2022 | 41-1 v SevillaBorussia Dortmund 1-1 Sevilla | UEFA Champions League Group G |
| 14 | Sun 16 Oct 2022 | 4 0-2 v 1 FC Union Berlin1 FC Union Berlin 2-0 Borussia Dortmund | German Bundesliga |
| 15 | Sat 22 Oct 2022 | 45-0 v VfB StuttgartBorussia Dortmund 5-0 VfB Stuttgart | German Bundesliga |
| 16 | Tue 25 Oct 2022 | 40-0 v Manchester CityBorussia Dortmund 0-0 Manchester City | UEFA Champions League Group G |
| 17 | Sat 29 Oct 2022 | 42-1 v Eintracht FrankfurtEintracht Frankfurt 1-2 Borussia Dortmund | German Bundesliga |
| 18 | Wed 2 Nov 2022 | 41-1 v FC CopenhagenFC Copenhagen 1-1 Borussia Dortmund | UEFA Champions League Group G |
| 19 | Sat 5 Nov 2022 | 43-0 v VfL BochumBorussia Dortmund 3-0 VfL Bochum | German Bundesliga |
| 20 | Tue 8 Nov 2022 | 40-2 v VfL WolfsburgVfL Wolfsburg 2-0 Borussia Dortmund | German Bundesliga |
| 21 | Fri 11 Nov 2022 | 42-4 v Borussia MönchengladbachBorussia Mönchengladbach 4-2 Borussia Dortmund | German Bundesliga |
| 22 | Sun 22 Jan 2023 | 44-3 v FC AugsburgBorussia Dortmund 4-3 FC Augsburg | German Bundesliga |
| 23 | Wed 25 Jan 2023 | 42-1 v Mainz 05Mainz 05 1-2 Borussia Dortmund | German Bundesliga |
| 24 | Sun 29 Jan 2023 | 42-0 v Bayer 04 LeverkusenBayer 04 Leverkusen 0-2 Borussia Dortmund | German Bundesliga |
| 25 | Sat 4 Feb 2023 | 45-1 v SC FreiburgBorussia Dortmund 5-1 SC Freiburg | German Bundesliga |
| 26 | Sat 11 Feb 2023 | 42-0 v Werder BremenWerder Bremen 0-2 Borussia Dortmund | German Bundesliga |
| 27 | Wed 15 Feb 2023 | 41-0 v ChelseaBorussia Dortmund 1-0 Chelsea | UEFA Champions League Round of 16 |
| 28 | Sun 19 Feb 2023 | 44-1 v Hertha BerlinBorussia Dortmund 4-1 Hertha Berlin | German Bundesliga |
| 29 | Sat 25 Feb 2023 | 41-0 v 1899 Hoffenheim1899 Hoffenheim 0-1 Borussia Dortmund | German Bundesliga |
| 30 | Fri 3 Mar 2023 | 42-1 v RB LeipzigBorussia Dortmund 2-1 RB Leipzig | German Bundesliga |
| 31 | Tue 7 Mar 2023 | 40-2 v ChelseaChelsea 2-0 Borussia Dortmund | UEFA Champions League Round of 16 |
| 32 | Sat 11 Mar 2023 | 42-2 v FC Schalke 04FC Schalke 04 2-2 Borussia Dortmund | German Bundesliga |
| 33 | Sat 18 Mar 2023 | 46-1 v 1 FC KölnBorussia Dortmund 6-1 1 FC Köln | German Bundesliga |
| 34 | Sat 1 Apr 2023 | 42-4 v Bayern MunichBayern Munich 4-2 Borussia Dortmund | German Bundesliga |
| 35 | Sat 22 Apr 2023 | 44-0 v Eintracht FrankfurtBorussia Dortmund 4-0 Eintracht Frankfurt | German Bundesliga |
| 36 | Sun 21 May 2023 | 43-0 v FC AugsburgFC Augsburg 0-3 Borussia Dortmund | German Bundesliga |
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