| 1 | Sat 23 Aug | 81-2 v TSG HoffenheimBayer Leverkusen 1-2 TSG Hoffenheim | German Bundesliga |
| 2 | Sat 30 Aug | 83-3 v Werder BremenWerder Bremen 3-3 Bayer Leverkusen | German Bundesliga |
| 3 | Fri 12 Sep | 8 3-1 v Eintracht FrankfurtBayer Leverkusen 3-1 Eintracht Frankfurt | German Bundesliga |
| 4 | Thu 18 Sep | 82-2 v FC CopenhagenFC Copenhagen 2-2 Bayer Leverkusen | UEFA Champions League Matchday 1 |
| 5 | Sat 27 Sep | 82-1 v FC St PauliFC St Pauli 1-2 Bayer Leverkusen | German Bundesliga |
| 6 | Sat 4 Oct | 82-0 v Union BerlinBayer Leverkusen 2-0 Union Berlin | German Bundesliga |
| 7 | Sat 18 Oct | 84-3 v Mainz 05Mainz 05 3-4 Bayer Leverkusen | German Bundesliga |
| 8 | Tue 21 Oct | 8 2-7 v Paris St GermainBayer Leverkusen 2-7 Paris St Germain | UEFA Champions League Matchday 3 |
| 9 | Sun 26 Oct | 82-0 v SC FreiburgBayer Leverkusen 2-0 SC Freiburg | German Bundesliga |
| 10 | Sat 1 Nov | 80-3 v Bayern MunichBayern Munich 3-0 Bayer Leverkusen | German Bundesliga |
| 11 | Sat 8 Nov | 86-0 v 1 FC HeidenheimBayer Leverkusen 6-0 1 FC Heidenheim | German Bundesliga |
| 12 | Sat 22 Nov | 8 3-1 v VfL WolfsburgVfL Wolfsburg 1-3 Bayer Leverkusen | German Bundesliga |
| 13 | Sat 29 Nov | 81-2 v Borussia DortmundBayer Leverkusen 1-2 Borussia Dortmund | German Bundesliga |
| 14 | Sat 6 Dec | 80-2 v FC AugsburgFC Augsburg 2-0 Bayer Leverkusen | German Bundesliga |
| 15 | Wed 10 Dec | 82-2 v Newcastle UnitedBayer Leverkusen 2-2 Newcastle United | UEFA Champions League Matchday 6 |
| 16 | Sat 13 Dec | 82-0 v 1 FC KölnBayer Leverkusen 2-0 1 FC Köln | German Bundesliga |
| 17 | Sat 20 Dec | 83-1 v RB LeipzigRB Leipzig 1-3 Bayer Leverkusen | German Bundesliga |
| 18 | Sat 10 Jan | 81-4 v VfB StuttgartBayer Leverkusen 1-4 VfB Stuttgart | German Bundesliga |
| 19 | Sat 17 Jan | 80-1 v TSG HoffenheimTSG Hoffenheim 1-0 Bayer Leverkusen | German Bundesliga |
| 20 | Tue 20 Jan | 80-2 v OlympiakosOlympiakos 2-0 Bayer Leverkusen | UEFA Champions League Matchday 7 |
| 21 | Sat 24 Jan | 81-0 v Werder BremenBayer Leverkusen 1-0 Werder Bremen | German Bundesliga |
| 22 | Wed 28 Jan | 83-0 v VillarrealBayer Leverkusen 3-0 Villarreal | UEFA Champions League Matchday 8 |
| 23 | Sat 31 Jan | 83-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 Bayer Leverkusen | German Bundesliga |
| 24 | Sat 7 Feb | 81-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 Bayer Leverkusen | German Bundesliga |
| 25 | Sat 14 Feb | 84-0 v FC St PauliBayer Leverkusen 4-0 FC St Pauli | German Bundesliga |
| 26 | Wed 18 Feb | 82-0 v OlympiakosOlympiakos 0-2 Bayer Leverkusen | UEFA Champions League Play-off Round of 32 |
| 27 | Sat 21 Feb | 8 0-1 v Union BerlinUnion Berlin 1-0 Bayer Leverkusen | German Bundesliga |
| 28 | Tue 24 Feb | 80-0 v OlympiakosBayer Leverkusen 0-0 Olympiakos | UEFA Champions League Play-off Round of 32 |
| 29 | Sat 28 Feb | 81-1 v Mainz 05Bayer Leverkusen 1-1 Mainz 05 | German Bundesliga |
| 30 | Wed 4 Mar | 81-0 v Hamburger SVHamburger SV 0-1 Bayer Leverkusen | German Bundesliga |
| 31 | Sat 7 Mar | 8 3-3 v SC FreiburgSC Freiburg 3-3 Bayer Leverkusen | German Bundesliga |
| 32 | Wed 11 Mar | 8 1-1 v ArsenalBayer Leverkusen 1-1 Arsenal | UEFA Champions League Round of 16 |
| 33 | Sat 14 Mar | 8 1-1 v Bayern MunichBayer Leverkusen 1-1 Bayern Munich | German Bundesliga |
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