| 1 | Sat 30 Aug | 53-3 v Werder BremenWerder Bremen 3-3 Bayer Leverkusen | German Bundesliga |
| 2 | Fri 12 Sep | 53-1 v Eintracht FrankfurtBayer Leverkusen 3-1 Eintracht Frankfurt | German Bundesliga |
| 3 | Thu 18 Sep | 52-2 v FC CopenhagenFC Copenhagen 2-2 Bayer Leverkusen | UEFA Champions League Matchday 1 |
| 4 | Sun 21 Sep | 5 1-1 v Borussia MönchengladbachBayer Leverkusen 1-1 Borussia Mönchengladbach | German Bundesliga |
| 5 | Sat 27 Sep | 5 2-1 v FC St PauliFC St Pauli 1-2 Bayer Leverkusen | German Bundesliga |
| 6 | Wed 1 Oct | 51-1 v PSV EindhovenBayer Leverkusen 1-1 PSV Eindhoven | UEFA Champions League Matchday 2 |
| 7 | Sat 4 Oct | 52-0 v Union BerlinBayer Leverkusen 2-0 Union Berlin | German Bundesliga |
| 8 | Sat 18 Oct | 5 4-3 v Mainz 05Mainz 05 3-4 Bayer Leverkusen | German Bundesliga |
| 9 | Tue 21 Oct | 52-7 v Paris St GermainBayer Leverkusen 2-7 Paris St Germain | UEFA Champions League Matchday 3 |
| 10 | Sun 26 Oct | 52-0 v SC FreiburgBayer Leverkusen 2-0 SC Freiburg | German Bundesliga |
| 11 | Sat 1 Nov | 50-3 v Bayern MunichBayern Munich 3-0 Bayer Leverkusen | German Bundesliga |
| 12 | Wed 5 Nov | 51-0 v BenficaBenfica 0-1 Bayer Leverkusen | UEFA Champions League Matchday 4 |
| 13 | Sat 8 Nov | 56-0 v 1 FC HeidenheimBayer Leverkusen 6-0 1 FC Heidenheim | German Bundesliga |
| 14 | Sat 22 Nov | 53-1 v VfL WolfsburgVfL Wolfsburg 1-3 Bayer Leverkusen | German Bundesliga |
| 15 | Tue 25 Nov | 52-0 v Manchester CityManchester City 0-2 Bayer Leverkusen | UEFA Champions League Matchday 5 |
| 16 | Sat 29 Nov | 51-2 v Borussia DortmundBayer Leverkusen 1-2 Borussia Dortmund | German Bundesliga |
| 17 | Sat 6 Dec | 50-2 v FC AugsburgFC Augsburg 2-0 Bayer Leverkusen | German Bundesliga |
| 18 | Sat 13 Dec | 52-0 v 1 FC KölnBayer Leverkusen 2-0 1 FC Köln | German Bundesliga |
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