| 1 | Sun 21 Sep | 7 1-1 v Borussia MönchengladbachBayer Leverkusen 1-1 Borussia Mönchengladbach | German Bundesliga |
| 2 | Sat 27 Sep | 72-1 v FC St PauliFC St Pauli 1-2 Bayer Leverkusen | German Bundesliga |
| 3 | Sat 4 Oct | 72-0 v Union BerlinBayer Leverkusen 2-0 Union Berlin | German Bundesliga |
| 4 | Sat 18 Oct | 74-3 v Mainz 05Mainz 05 3-4 Bayer Leverkusen | German Bundesliga |
| 5 | Sun 26 Oct | 72-0 v SC FreiburgBayer Leverkusen 2-0 SC Freiburg | German Bundesliga |
| 6 | Sat 1 Nov | 70-3 v Bayern MunichBayern Munich 3-0 Bayer Leverkusen | German Bundesliga |
| 7 | Sat 8 Nov | 76-0 v 1 FC HeidenheimBayer Leverkusen 6-0 1 FC Heidenheim | German Bundesliga |
| 8 | Sat 22 Nov | 73-1 v VfL WolfsburgVfL Wolfsburg 1-3 Bayer Leverkusen | German Bundesliga |
| 9 | Sat 29 Nov | 71-2 v Borussia DortmundBayer Leverkusen 1-2 Borussia Dortmund | German Bundesliga |
| 10 | Sat 6 Dec | 70-2 v FC AugsburgFC Augsburg 2-0 Bayer Leverkusen | German Bundesliga |
| 11 | Sat 13 Dec | 72-0 v 1 FC KölnBayer Leverkusen 2-0 1 FC Köln | German Bundesliga |
| 12 | Sat 20 Dec | 73-1 v RB LeipzigRB Leipzig 1-3 Bayer Leverkusen | German Bundesliga |
| 13 | Sat 10 Jan | 71-4 v VfB StuttgartBayer Leverkusen 1-4 VfB Stuttgart | German Bundesliga |
| 14 | Sat 24 Jan | 7 1-0 v Werder BremenBayer Leverkusen 1-0 Werder Bremen | German Bundesliga |
| 15 | Sat 31 Jan | 73-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 Bayer Leverkusen | German Bundesliga |
| 16 | Sat 7 Feb | 71-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 Bayer Leverkusen | German Bundesliga |
| 17 | Sat 14 Feb | 74-0 v FC St PauliBayer Leverkusen 4-0 FC St Pauli | German Bundesliga |
| 18 | Sat 21 Feb | 7 0-1 v Union BerlinUnion Berlin 1-0 Bayer Leverkusen | German Bundesliga |
| 19 | Tue 24 Feb | 70-0 v OlympiakosBayer Leverkusen 0-0 Olympiakos | UEFA Champions League Play-off Round of 32 |
| 20 | Sat 28 Feb | 71-1 v Mainz 05Bayer Leverkusen 1-1 Mainz 05 | German Bundesliga |
| 21 | Wed 11 Mar | 71-1 v ArsenalBayer Leverkusen 1-1 Arsenal | UEFA Champions League Round of 16 |
| 22 | Sat 14 Mar | 71-1 v Bayern MunichBayer Leverkusen 1-1 Bayern Munich | German Bundesliga |
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