| 1 | Fri 12 Sep | 6 3-1 v Eintracht FrankfurtBayer Leverkusen 3-1 Eintracht Frankfurt | German Bundesliga |
| 2 | Thu 18 Sep | 62-2 v FC CopenhagenFC Copenhagen 2-2 Bayer Leverkusen | UEFA Champions League Matchday 1 |
| 3 | Sat 27 Sep | 6 2-1 v FC St PauliFC St Pauli 1-2 Bayer Leverkusen | German Bundesliga |
| 4 | Wed 1 Oct | 61-1 v PSV EindhovenBayer Leverkusen 1-1 PSV Eindhoven | UEFA Champions League Matchday 2 |
| 5 | Sat 4 Oct | 62-0 v Union BerlinBayer Leverkusen 2-0 Union Berlin | German Bundesliga |
| 6 | Sat 18 Oct | 64-3 v Mainz 05Mainz 05 3-4 Bayer Leverkusen | German Bundesliga |
| 7 | Tue 21 Oct | 62-7 v Paris St GermainBayer Leverkusen 2-7 Paris St Germain | UEFA Champions League Matchday 3 |
| 8 | Sun 26 Oct | 62-0 v SC FreiburgBayer Leverkusen 2-0 SC Freiburg | German Bundesliga |
| 9 | Sat 20 Dec | 63-1 v RB LeipzigRB Leipzig 1-3 Bayer Leverkusen | German Bundesliga |
| 10 | Sat 10 Jan | 61-4 v VfB StuttgartBayer Leverkusen 1-4 VfB Stuttgart | German Bundesliga |
| 11 | Sat 17 Jan | 60-1 v TSG HoffenheimTSG Hoffenheim 1-0 Bayer Leverkusen | German Bundesliga |
| 12 | Tue 20 Jan | 60-2 v OlympiakosOlympiakos 2-0 Bayer Leverkusen | UEFA Champions League Matchday 7 |
| 13 | Sat 24 Jan | 61-0 v Werder BremenBayer Leverkusen 1-0 Werder Bremen | German Bundesliga |
| 14 | Wed 28 Jan | 63-0 v VillarrealBayer Leverkusen 3-0 Villarreal | UEFA Champions League Matchday 8 |
| 15 | Sat 31 Jan | 63-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 Bayer Leverkusen | German Bundesliga |
| 16 | Sat 7 Feb | 61-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 Bayer Leverkusen | German Bundesliga |
| 17 | Wed 18 Feb | 62-0 v OlympiakosOlympiakos 0-2 Bayer Leverkusen | UEFA Champions League Play-off Round of 32 |
| 18 | Sat 21 Feb | 60-1 v Union BerlinUnion Berlin 1-0 Bayer Leverkusen | German Bundesliga |
| 19 | Tue 24 Feb | 60-0 v OlympiakosBayer Leverkusen 0-0 Olympiakos | UEFA Champions League Play-off Round of 32 |
| 20 | Sat 28 Feb | 61-1 v Mainz 05Bayer Leverkusen 1-1 Mainz 05 | German Bundesliga |
| 21 | Wed 4 Mar | 61-0 v Hamburger SVHamburger SV 0-1 Bayer Leverkusen | German Bundesliga |
| 22 | Sat 7 Mar | 63-3 v SC FreiburgSC Freiburg 3-3 Bayer Leverkusen | German Bundesliga |
| 23 | Wed 11 Mar | 61-1 v ArsenalBayer Leverkusen 1-1 Arsenal | UEFA Champions League Round of 16 |
| 24 | Sat 14 Mar | 6 1-1 v Bayern MunichBayer Leverkusen 1-1 Bayern Munich | German Bundesliga |
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