| 1 | Sat 30 Aug | 253-3 v Werder BremenWerder Bremen 3-3 Bayer Leverkusen | German Bundesliga |
| 2 | Fri 12 Sep | 253-1 v Eintracht FrankfurtBayer Leverkusen 3-1 Eintracht Frankfurt | German Bundesliga |
| 3 | Sat 24 Jan | 251-0 v Werder BremenBayer Leverkusen 1-0 Werder Bremen | German Bundesliga |
| 4 | Wed 28 Jan | 253-0 v VillarrealBayer Leverkusen 3-0 Villarreal | UEFA Champions League Matchday 8 |
| 5 | Sat 31 Jan | 253-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 Bayer Leverkusen | German Bundesliga |
| 6 | Sat 7 Feb | 25 1-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 Bayer Leverkusen | German Bundesliga |
| 7 | Sat 14 Feb | 254-0 v FC St PauliBayer Leverkusen 4-0 FC St Pauli | German Bundesliga |
| 8 | Wed 18 Feb | 252-0 v OlympiakosOlympiakos 0-2 Bayer Leverkusen | UEFA Champions League Play-off Round of 32 |
| 9 | Tue 24 Feb | 250-0 v OlympiakosBayer Leverkusen 0-0 Olympiakos | UEFA Champions League Play-off Round of 32 |
| 10 | Sat 28 Feb | 251-1 v Mainz 05Bayer Leverkusen 1-1 Mainz 05 | German Bundesliga |
| 11 | Wed 4 Mar | 25 1-0 v Hamburger SVHamburger SV 0-1 Bayer Leverkusen | German Bundesliga |
| 12 | Sat 7 Mar | 253-3 v SC FreiburgSC Freiburg 3-3 Bayer Leverkusen | German Bundesliga |
| 13 | Wed 11 Mar | 25 1-1 v ArsenalBayer Leverkusen 1-1 Arsenal | UEFA Champions League Round of 16 |
| 14 | Sat 14 Mar | 251-1 v Bayern MunichBayer Leverkusen 1-1 Bayern Munich | German Bundesliga |
| 15 | Tue 17 Mar | 25 0-2 v ArsenalArsenal 2-0 Bayer Leverkusen | UEFA Champions League Round of 16 |
| 16 | Sat 21 Mar | 253-3 v 1 FC Heidenheim1 FC Heidenheim 3-3 Bayer Leverkusen | German Bundesliga |
| 17 | Sat 4 Apr | 256-3 v VfL WolfsburgBayer Leverkusen 6-3 VfL Wolfsburg | German Bundesliga |
| 18 | Sat 11 Apr | 251-0 v Borussia DortmundBorussia Dortmund 0-1 Bayer Leverkusen | German Bundesliga |
| 19 | Sat 18 Apr | 251-2 v FC AugsburgBayer Leverkusen 1-2 FC Augsburg | German Bundesliga |
| 20 | Sat 25 Apr | 252-1 v 1 FC Köln1 FC Köln 1-2 Bayer Leverkusen | German Bundesliga |
| 21 | Sat 2 May | 254-1 v RB LeipzigBayer Leverkusen 4-1 RB Leipzig | German Bundesliga |
| 22 | Sat 9 May | 25 1-3 v VfB StuttgartVfB Stuttgart 3-1 Bayer Leverkusen | German Bundesliga |
| 23 | Sat 16 May | 251-1 v Hamburger SVBayer Leverkusen 1-1 Hamburger SV | German Bundesliga |
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