| 1 | Fri 23 Aug | 83-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Sat 14 Sep | 8 4-1 v 1899 Hoffenheim1899 Hoffenheim 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 3 | Thu 19 Sep | 84-0 v FeyenoordFeyenoord 0-4 Bayer 04 Leverkusen | UEFA Champions League Matchday 1 |
| 4 | Sat 28 Sep | 8 1-1 v Bayern MunichBayern Munich 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 5 | Tue 1 Oct | 81-0 v AC MilanBayer 04 Leverkusen 1-0 AC Milan | UEFA Champions League Matchday 2 |
| 6 | Sat 5 Oct | 82-2 v Holstein KielBayer 04 Leverkusen 2-2 Holstein Kiel | German Bundesliga |
| 7 | Sat 19 Oct | 82-1 v Eintracht FrankfurtBayer 04 Leverkusen 2-1 Eintracht Frankfurt | German Bundesliga |
| 8 | Sat 26 Oct | 82-2 v Werder BremenWerder Bremen 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 9 | Fri 1 Nov | 8 0-0 v VfB StuttgartBayer 04 Leverkusen 0-0 VfB Stuttgart | German Bundesliga |
| 10 | Tue 5 Nov | 80-4 v LiverpoolLiverpool 4-0 Bayer 04 Leverkusen | UEFA Champions League Matchday 4 |
| 11 | Sat 9 Nov | 81-1 v VfL BochumVfL Bochum 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 12 | Sat 23 Nov | 85-2 v 1 FC HeidenheimBayer 04 Leverkusen 5-2 1 FC Heidenheim | German Bundesliga |
| 13 | Tue 26 Nov | 8 5-0 v SV Red Bull SalzburgBayer 04 Leverkusen 5-0 SV Red Bull Salzburg | UEFA Champions League Matchday 5 |
| 14 | Sat 30 Nov | 8 2-1 v 1 FC Union Berlin1 FC Union Berlin 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 15 | Sat 7 Dec | 82-1 v FC St PauliBayer 04 Leverkusen 2-1 FC St Pauli | German Bundesliga |
| 16 | Tue 10 Dec | 81-0 v Inter MilanBayer 04 Leverkusen 1-0 Inter Milan | UEFA Champions League Matchday 6 |
| 17 | Sat 14 Dec | 82-0 v FC AugsburgFC Augsburg 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Fri 10 Jan | 83-2 v Borussia DortmundBorussia Dortmund 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 19 | Sat 18 Jan | 83-1 v Borussia MönchengladbachBayer 04 Leverkusen 3-1 Borussia Mönchengladbach | German Bundesliga |
| 20 | Sat 25 Jan | 8 2-2 v RB LeipzigRB Leipzig 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 21 | Wed 29 Jan | 8 2-0 v Sparta PragueBayer 04 Leverkusen 2-0 Sparta Prague | UEFA Champions League Matchday 8 |
| 22 | Sat 8 Feb | 8 0-0 v VfL WolfsburgVfL Wolfsburg 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 23 | Sat 22 Feb | 82-0 v Holstein KielHolstein Kiel 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 24 | Tue 11 Mar | 80-2 v Bayern MunichBayer 04 Leverkusen 0-2 Bayern Munich | UEFA Champions League Round of 16 |
| 25 | Sun 16 Mar | 8 4-3 v VfB StuttgartVfB Stuttgart 3-4 Bayer 04 Leverkusen | German Bundesliga |
| 26 | Fri 28 Mar | 83-1 v VfL BochumBayer 04 Leverkusen 3-1 VfL Bochum | German Bundesliga |
| 27 | Sat 5 Apr | 81-0 v 1 FC Heidenheim1 FC Heidenheim 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 28 | Sat 26 Apr | 82-0 v FC AugsburgBayer 04 Leverkusen 2-0 FC Augsburg | German Bundesliga |
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