| 1 | Fri 23 Aug | 33-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Sat 31 Aug | 32-3 v RB LeipzigBayer 04 Leverkusen 2-3 RB Leipzig | German Bundesliga |
| 3 | Sat 14 Sep | 34-1 v 1899 Hoffenheim1899 Hoffenheim 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Thu 19 Sep | 34-0 v FeyenoordFeyenoord 0-4 Bayer 04 Leverkusen | UEFA Champions League Matchday 1 |
| 5 | Sun 22 Sep | 34-3 v VfL WolfsburgBayer 04 Leverkusen 4-3 VfL Wolfsburg | German Bundesliga |
| 6 | Sat 28 Sep | 31-1 v Bayern MunichBayern Munich 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 7 | Tue 1 Oct | 31-0 v AC MilanBayer 04 Leverkusen 1-0 AC Milan | UEFA Champions League Matchday 2 |
| 8 | Sat 5 Oct | 32-2 v Holstein KielBayer 04 Leverkusen 2-2 Holstein Kiel | German Bundesliga |
| 9 | Sat 19 Oct | 3 2-1 v Eintracht FrankfurtBayer 04 Leverkusen 2-1 Eintracht Frankfurt | German Bundesliga |
| 10 | Wed 23 Oct | 31-1 v BrestBrest 1-1 Bayer 04 Leverkusen | UEFA Champions League Matchday 3 |
| 11 | Sat 26 Oct | 3 2-2 v Werder BremenWerder Bremen 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 12 | Fri 1 Nov | 30-0 v VfB StuttgartBayer 04 Leverkusen 0-0 VfB Stuttgart | German Bundesliga |
| 13 | Tue 5 Nov | 30-4 v LiverpoolLiverpool 4-0 Bayer 04 Leverkusen | UEFA Champions League Matchday 4 |
| 14 | Sat 9 Nov | 31-1 v VfL BochumVfL Bochum 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 15 | Sat 23 Nov | 35-2 v 1 FC HeidenheimBayer 04 Leverkusen 5-2 1 FC Heidenheim | German Bundesliga |
| 16 | Tue 26 Nov | 35-0 v SV Red Bull SalzburgBayer 04 Leverkusen 5-0 SV Red Bull Salzburg | UEFA Champions League Matchday 5 |
| 17 | Sat 30 Nov | 32-1 v 1 FC Union Berlin1 FC Union Berlin 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Sat 7 Dec | 3 2-1 v FC St PauliBayer 04 Leverkusen 2-1 FC St Pauli | German Bundesliga |
| 19 | Tue 10 Dec | 31-0 v Inter MilanBayer 04 Leverkusen 1-0 Inter Milan | UEFA Champions League Matchday 6 |
| 20 | Sat 14 Dec | 32-0 v FC AugsburgFC Augsburg 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 21 | Sat 21 Dec | 35-1 v SC FreiburgBayer 04 Leverkusen 5-1 SC Freiburg | German Bundesliga |
| 22 | Fri 10 Jan | 33-2 v Borussia DortmundBorussia Dortmund 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 23 | Tue 14 Jan | 31-0 v Mainz 05Bayer 04 Leverkusen 1-0 Mainz 05 | German Bundesliga |
| 24 | Sat 18 Jan | 33-1 v Borussia MönchengladbachBayer 04 Leverkusen 3-1 Borussia Mönchengladbach | German Bundesliga |
| 25 | Tue 21 Jan | 3 1-2 v Atlético MadridAtlético Madrid 2-1 Bayer 04 Leverkusen | UEFA Champions League Matchday 7 |
| 26 | Sat 25 Jan | 32-2 v RB LeipzigRB Leipzig 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 27 | Sun 2 Feb | 33-1 v 1899 HoffenheimBayer 04 Leverkusen 3-1 1899 Hoffenheim | German Bundesliga |
| 28 | Sat 8 Feb | 30-0 v VfL WolfsburgVfL Wolfsburg 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 29 | Sat 15 Feb | 3 0-0 v Bayern MunichBayer 04 Leverkusen 0-0 Bayern Munich | German Bundesliga |
| 30 | Sat 22 Feb | 3 2-0 v Holstein KielHolstein Kiel 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 31 | Wed 5 Mar | 30-3 v Bayern MunichBayern Munich 3-0 Bayer 04 Leverkusen | UEFA Champions League Round of 16 |
| 32 | Tue 11 Mar | 30-2 v Bayern MunichBayer 04 Leverkusen 0-2 Bayern Munich | UEFA Champions League Round of 16 |
| 33 | Sun 16 Mar | 3 4-3 v VfB StuttgartVfB Stuttgart 3-4 Bayer 04 Leverkusen | German Bundesliga |
| 34 | Fri 28 Mar | 33-1 v VfL BochumBayer 04 Leverkusen 3-1 VfL Bochum | German Bundesliga |
| 35 | Sat 5 Apr | 31-0 v 1 FC Heidenheim1 FC Heidenheim 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 36 | Sat 12 Apr | 30-0 v 1 FC Union BerlinBayer 04 Leverkusen 0-0 1 FC Union Berlin | German Bundesliga |
| 37 | Sun 20 Apr | 3 1-1 v FC St PauliFC St Pauli 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 38 | Sat 26 Apr | 32-0 v FC AugsburgBayer 04 Leverkusen 2-0 FC Augsburg | German Bundesliga |
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