| 1 | Sat 6 Aug 2022 | 140-1 v Borussia DortmundBorussia Dortmund 1-0 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Sat 13 Aug 2022 | 141-2 v FC AugsburgBayer 04 Leverkusen 1-2 FC Augsburg | German Bundesliga |
| 3 | Sat 20 Aug 2022 | 140-3 v 1899 HoffenheimBayer 04 Leverkusen 0-3 1899 Hoffenheim | German Bundesliga |
| 4 | Sat 27 Aug 2022 | 143-0 v Mainz 05Mainz 05 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 5 | Sat 3 Sep 2022 | 142-3 v SC FreiburgBayer 04 Leverkusen 2-3 SC Freiburg | German Bundesliga |
| 6 | Wed 7 Sep 2022 | 140-1 v Club BruggeClub Brugge 1-0 Bayer 04 Leverkusen | UEFA Champions League Group B |
| 7 | Sat 10 Sep 2022 | 142-2 v Hertha BerlinHertha Berlin 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 8 | Tue 13 Sep 2022 | 142-0 v Atlético MadridBayer 04 Leverkusen 2-0 Atlético Madrid | UEFA Champions League Group B |
| 9 | Sat 17 Sep 2022 | 141-1 v Werder BremenBayer 04 Leverkusen 1-1 Werder Bremen | German Bundesliga |
| 10 | Fri 30 Sep 2022 | 140-4 v Bayern MunichBayern Munich 4-0 Bayer 04 Leverkusen | German Bundesliga |
| 11 | Tue 4 Oct 2022 | 140-2 v FC PortoFC Porto 2-0 Bayer 04 Leverkusen | UEFA Champions League Group B |
| 12 | Sat 8 Oct 2022 | 144-0 v FC Schalke 04Bayer 04 Leverkusen 4-0 FC Schalke 04 | German Bundesliga |
| 13 | Wed 12 Oct 2022 | 140-3 v FC PortoBayer 04 Leverkusen 0-3 FC Porto | UEFA Champions League Group B |
| 14 | Sat 15 Oct 2022 | 141-5 v Eintracht FrankfurtEintracht Frankfurt 5-1 Bayer 04 Leverkusen | German Bundesliga |
| 15 | Sat 29 Oct 2022 | 140-2 v RB LeipzigRB Leipzig 2-0 Bayer 04 Leverkusen | German Bundesliga |
| 16 | Tue 1 Nov 2022 | 140-0 v Club BruggeBayer 04 Leverkusen 0-0 Club Brugge | UEFA Champions League Group B |
| 17 | Thu 16 Feb 2023 | 142-3 v MonacoBayer 04 Leverkusen 2-3 Monaco | UEFA Europa League |
| 18 | Sun 19 Feb 2023 | 142-3 v Mainz 05Bayer 04 Leverkusen 2-3 Mainz 05 | German Bundesliga |
| 19 | Thu 23 Feb 2023 | 143-2 v MonacoMonaco 2-3 Bayer 04 Leverkusen | UEFA Europa League |
| 20 | Sun 26 Feb 2023 | 141-1 v SC FreiburgSC Freiburg 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 21 | Sun 5 Mar 2023 | 144-1 v Hertha BerlinBayer 04 Leverkusen 4-1 Hertha Berlin | German Bundesliga |
| 22 | Thu 9 Mar 2023 | 142-0 v Ferencvárosi TCBayer 04 Leverkusen 2-0 Ferencvárosi TC | UEFA Europa League Round of 16 |
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