| 1 | Sat 14 Aug 2021 | 141-1 v 1. FC Union Berlin1. FC Union Berlin 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 144-0 v Borussia MönchengladbachBayer 04 Leverkusen 4-0 Borussia Mönchengladbach | German Bundesliga |
| 3 | Sat 28 Aug 2021 | 144-1 v FC AugsburgFC Augsburg 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Sat 11 Sep 2021 | 143-4 v Borussia DortmundBayer 04 Leverkusen 3-4 Borussia Dortmund | German Bundesliga |
| 5 | Thu 16 Sep 2021 | 142-1 v Ferencvárosi TCBayer 04 Leverkusen 2-1 Ferencvárosi TC | UEFA Europa League Group G |
| 6 | Sun 19 Sep 2021 | 143-1 v VfB StuttgartVfB Stuttgart 1-3 Bayer 04 Leverkusen | German Bundesliga |
| 7 | Sat 25 Sep 2021 | 141-0 v Mainz 05Bayer 04 Leverkusen 1-0 Mainz 05 | German Bundesliga |
| 8 | Thu 30 Sep 2021 | 144-0 v CelticCeltic 0-4 Bayer 04 Leverkusen | UEFA Europa League Group G |
| 9 | Sun 3 Oct 2021 | 144-0 v Arminia BielefeldArminia Bielefeld 0-4 Bayer 04 Leverkusen | German Bundesliga |
| 10 | Sun 17 Oct 2021 | 141-5 v Bayern MunichBayer 04 Leverkusen 1-5 Bayern Munich | German Bundesliga |
| 11 | Thu 21 Oct 2021 | 141-1 v Real BetisReal Betis 1-1 Bayer 04 Leverkusen | UEFA Europa League Group G |
| 12 | Sun 24 Oct 2021 | 142-2 v 1. FC Köln1. FC Köln 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 13 | Sun 28 Nov 2021 | 143-1 v RB LeipzigRB Leipzig 1-3 Bayer 04 Leverkusen | German Bundesliga |
| 14 | Sat 4 Dec 2021 | 147-1 v Greuther FürthBayer 04 Leverkusen 7-1 Greuther Fürth | German Bundesliga |
| 15 | Sun 12 Dec 2021 | 142-5 v Eintracht FrankfurtEintracht Frankfurt 5-2 Bayer 04 Leverkusen | German Bundesliga |
| 16 | Wed 15 Dec 2021 | 142-2 v 1899 HoffenheimBayer 04 Leverkusen 2-2 1899 Hoffenheim | German Bundesliga |
| 17 | Sun 19 Dec 2021 | 141-2 v SC FreiburgSC Freiburg 2-1 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Sat 8 Jan 2022 | 142-2 v 1. FC Union BerlinBayer 04 Leverkusen 2-2 1. FC Union Berlin | German Bundesliga |
| 19 | Sat 15 Jan 2022 | 142-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 20 | Sat 22 Jan 2022 | 145-1 v FC AugsburgBayer 04 Leverkusen 5-1 FC Augsburg | German Bundesliga |
| 21 | Sun 6 Feb 2022 | 145-2 v Borussia DortmundBorussia Dortmund 2-5 Bayer 04 Leverkusen | German Bundesliga |
| 22 | Sat 12 Feb 2022 | 144-2 v VfB StuttgartBayer 04 Leverkusen 4-2 VfB Stuttgart | German Bundesliga |
| 23 | Fri 18 Feb 2022 | 142-3 v Mainz 05Mainz 05 3-2 Bayer 04 Leverkusen | German Bundesliga |
| 24 | Sat 2 Apr 2022 | 142-1 v Hertha BerlinBayer 04 Leverkusen 2-1 Hertha Berlin | German Bundesliga |
| 25 | Sun 10 Apr 2022 | 140-0 v VfL BochumVfL Bochum 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 26 | Sun 17 Apr 2022 | 140-1 v RB LeipzigBayer 04 Leverkusen 0-1 RB Leipzig | German Bundesliga |
| 27 | Sat 23 Apr 2022 | 144-1 v Greuther FürthGreuther Fürth 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 28 | Mon 2 May 2022 | 142-0 v Eintracht FrankfurtBayer 04 Leverkusen 2-0 Eintracht Frankfurt | German Bundesliga |
| 29 | Sat 7 May 2022 | 144-2 v 1899 Hoffenheim1899 Hoffenheim 2-4 Bayer 04 Leverkusen | German Bundesliga |
| 30 | Sat 14 May 2022 | 142-1 v SC FreiburgBayer 04 Leverkusen 2-1 SC Freiburg | German Bundesliga |
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