| 1 | Sat 7 Aug 2021 | 281-1 v Cardiff CityCardiff City 1-1 Barnsley | Sky Bet Championship |
| 2 | Sat 14 Aug 2021 | 28 1-0 v Coventry CityBarnsley 1-0 Coventry City | Sky Bet Championship |
| 3 | Tue 17 Aug 2021 | 280-1 v Luton TownBarnsley 0-1 Luton Town | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 282-2 v Queens Park RangersQueens Park Rangers 2-2 Barnsley | Sky Bet Championship |
| 5 | Sat 28 Aug 2021 | 281-1 v Birmingham CityBarnsley 1-1 Birmingham City | Sky Bet Championship |
| 6 | Sat 11 Sep 2021 | 280-3 v AFC BournemouthAFC Bournemouth 3-0 Barnsley | Sky Bet Championship |
| 7 | Wed 15 Sep 2021 | 281-1 v Stoke CityStoke City 1-1 Barnsley | Sky Bet Championship |
| 8 | Sat 18 Sep 2021 | 280-0 v Blackburn RoversBarnsley 0-0 Blackburn Rovers | Sky Bet Championship |
| 9 | Sat 25 Sep 2021 | 280-1 v BlackpoolBlackpool 1-0 Barnsley | Sky Bet Championship |
| 10 | Wed 29 Sep 2021 | 281-3 v Nottingham ForestBarnsley 1-3 Nottingham Forest | Sky Bet Championship |
| 11 | Sat 2 Oct 2021 | 280-1 v MillwallBarnsley 0-1 Millwall | Sky Bet Championship |
| 12 | Sun 24 Oct 2021 | 282-3 v Sheffield UnitedBarnsley 2-3 Sheffield United | Sky Bet Championship |
| 13 | Sat 20 Nov 2021 | 281-4 v FulhamFulham 4-1 Barnsley | Sky Bet Championship |
| 14 | Wed 24 Nov 2021 | 280-2 v Swansea CityBarnsley 0-2 Swansea City | Sky Bet Championship |
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