| 1 | Wed 15 Sep 2021 | 160-0 v FC PortoAtlético Madrid 0-0 FC Porto | UEFA Champions League Group B |
| 2 | Sat 18 Sep 2021 | 160-0 v Athletic BilbaoAtlético Madrid 0-0 Athletic Bilbao | Spanish La Liga |
| 3 | Tue 21 Sep 2021 | 16 2-1 v GetafeGetafe 1-2 Atlético Madrid | Spanish La Liga |
| 4 | Sat 25 Sep 2021 | 160-1 v AlavésAlavés 1-0 Atlético Madrid | Spanish La Liga |
| 5 | Sun 24 Oct 2021 | 162-2 v Real SociedadAtlético Madrid 2-2 Real Sociedad | Spanish La Liga |
| 6 | Thu 28 Oct 2021 | 162-2 v LevanteLevante 2-2 Atlético Madrid | Spanish La Liga |
| 7 | Sun 31 Oct 2021 | 163-0 v Real BetisAtlético Madrid 3-0 Real Betis | Spanish La Liga |
| 8 | Wed 3 Nov 2021 | 160-2 v LiverpoolLiverpool 2-0 Atlético Madrid | UEFA Champions League Group B |
| 9 | Sun 7 Nov 2021 | 163-3 v ValenciaValencia 3-3 Atlético Madrid | Spanish La Liga |
| 10 | Sun 12 Dec 2021 | 160-2 v Real MadridReal Madrid 2-0 Atlético Madrid | Spanish La Liga |
| 11 | Wed 22 Dec 2021 | 161-2 v GranadaGranada 2-1 Atlético Madrid | Spanish La Liga |
| 12 | Sat 22 Jan 2022 | 16 3-2 v ValenciaAtlético Madrid 3-2 Valencia | Spanish La Liga |
| 13 | Sun 6 Feb 2022 | 16 2-4 v BarcelonaBarcelona 4-2 Atlético Madrid | Spanish La Liga |
| 14 | Sat 12 Feb 2022 | 164-3 v GetafeAtlético Madrid 4-3 Getafe | Spanish La Liga |
| 15 | Wed 16 Feb 2022 | 160-1 v LevanteAtlético Madrid 0-1 Levante | Spanish La Liga |
| 16 | Sat 19 Feb 2022 | 163-0 v OsasunaOsasuna 0-3 Atlético Madrid | Spanish La Liga |
| 17 | Wed 23 Feb 2022 | 16 1-1 v Manchester UnitedAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 18 | Sat 26 Feb 2022 | 162-0 v Celta VigoAtlético Madrid 2-0 Celta Vigo | Spanish La Liga |
| 19 | Sun 6 Mar 2022 | 16 3-1 v Real BetisReal Betis 1-3 Atlético Madrid | Spanish La Liga |
| 20 | Fri 11 Mar 2022 | 162-1 v CádizAtlético Madrid 2-1 Cádiz | Spanish La Liga |
| 21 | Tue 15 Mar 2022 | 16 1-0 v Manchester UnitedManchester United 0-1 Atlético Madrid | UEFA Champions League Round of 16 |
| 22 | Sat 19 Mar 2022 | 161-0 v Rayo VallecanoRayo Vallecano 0-1 Atlético Madrid | Spanish La Liga |
| 23 | Sat 30 Apr 2022 | 160-2 v Athletic BilbaoAthletic Bilbao 2-0 Atlético Madrid | Spanish La Liga |
| 24 | Wed 11 May 2022 | 162-0 v ElcheElche 0-2 Atlético Madrid | Spanish La Liga |
| 25 | Sun 15 May 2022 | 161-1 v SevillaAtlético Madrid 1-1 Sevilla | Spanish La Liga |
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