| 1 | Sat 17 Aug | 42-1 v West Ham UnitedWest Ham United 1-2 Aston Villa | Premier League |
| 2 | Sat 24 Aug | 40-2 v ArsenalAston Villa 0-2 Arsenal | Premier League |
| 3 | Sat 31 Aug | 42-1 v Leicester CityLeicester City 1-2 Aston Villa | Premier League |
| 4 | Sat 14 Sep | 43-2 v EvertonAston Villa 3-2 Everton | Premier League |
| 5 | Tue 17 Sep | 43-0 v Young BoysYoung Boys 0-3 Aston Villa | UEFA Champions League Matchday 1 |
| 6 | Sat 21 Sep | 43-1 v Wolverhampton WanderersAston Villa 3-1 Wolverhampton Wanderers | Premier League |
| 7 | Sun 29 Sep | 42-2 v Ipswich TownIpswich Town 2-2 Aston Villa | Premier League |
| 8 | Wed 2 Oct | 41-0 v Bayern MunichAston Villa 1-0 Bayern Munich | UEFA Champions League Matchday 2 |
| 9 | Sun 6 Oct | 40-0 v Manchester UnitedAston Villa 0-0 Manchester United | Premier League |
| 10 | Tue 22 Oct | 42-0 v BolognaAston Villa 2-0 Bologna | UEFA Champions League Matchday 3 |
| 11 | Sat 26 Oct | 41-1 v AFC BournemouthAston Villa 1-1 AFC Bournemouth | Premier League |
| 12 | Sun 3 Nov | 41-4 v Tottenham HotspurTottenham Hotspur 4-1 Aston Villa | Premier League |
| 13 | Wed 6 Nov | 4 0-1 v Club BruggeClub Brugge 1-0 Aston Villa | UEFA Champions League Matchday 4 |
| 14 | Sat 9 Nov | 40-2 v LiverpoolLiverpool 2-0 Aston Villa | Premier League |
| 15 | Sun 1 Dec | 40-3 v ChelseaChelsea 3-0 Aston Villa | Premier League |
| 16 | Wed 4 Dec | 43-1 v BrentfordAston Villa 3-1 Brentford | Premier League |
| 17 | Sat 7 Dec | 41-0 v SouthamptonAston Villa 1-0 Southampton | Premier League |
| 18 | Tue 10 Dec | 43-2 v RB LeipzigRB Leipzig 2-3 Aston Villa | UEFA Champions League Matchday 6 |
| 19 | Sat 14 Dec | 41-2 v Nottingham ForestNottingham Forest 2-1 Aston Villa | Premier League |
| 20 | Sat 21 Dec | 42-1 v Manchester CityAston Villa 2-1 Manchester City | Premier League |
| 21 | Thu 26 Dec | 40-3 v Newcastle UnitedNewcastle United 3-0 Aston Villa | Premier League |
| 22 | Mon 30 Dec | 42-2 v Brighton & Hove AlbionAston Villa 2-2 Brighton & Hove Albion | Premier League |
| 23 | Sat 4 Jan | 42-1 v Leicester CityAston Villa 2-1 Leicester City | Premier League |
| 24 | Fri 10 Jan | 42-1 v West Ham UnitedAston Villa 2-1 West Ham United | Emirates FA Cup Third Round |
| 25 | Wed 15 Jan | 41-0 v EvertonEverton 0-1 Aston Villa | Premier League |
| 26 | Sat 18 Jan | 42-2 v ArsenalArsenal 2-2 Aston Villa | Premier League |
| 27 | Tue 21 Jan | 40-1 v MonacoMonaco 1-0 Aston Villa | UEFA Champions League Matchday 7 |
| 28 | Sun 26 Jan | 41-1 v West Ham UnitedAston Villa 1-1 West Ham United | Premier League |
| 29 | Wed 29 Jan | 44-2 v CelticAston Villa 4-2 Celtic | UEFA Champions League Matchday 8 |
| 30 | Sat 1 Feb | 40-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Aston Villa | Premier League |
| 31 | Sun 9 Feb | 42-1 v Tottenham HotspurAston Villa 2-1 Tottenham Hotspur | Emirates FA Cup Fourth Round |
| 32 | Sat 22 Feb | 42-1 v ChelseaAston Villa 2-1 Chelsea | Premier League |
| 33 | Tue 25 Feb | 41-4 v Crystal PalaceCrystal Palace 4-1 Aston Villa | Premier League |
| 34 | Fri 28 Feb | 42-0 v Cardiff CityAston Villa 2-0 Cardiff City | Emirates FA Cup Fifth Round |
| 35 | Tue 4 Mar | 43-1 v Club BruggeClub Brugge 1-3 Aston Villa | UEFA Champions League Round of 16 |
| 36 | Sat 8 Mar | 41-0 v BrentfordBrentford 0-1 Aston Villa | Premier League |
| 37 | Wed 12 Mar | 43-0 v Club BruggeAston Villa 3-0 Club Brugge | UEFA Champions League Round of 16 |
| 38 | Sun 30 Mar | 43-0 v Preston North EndPreston North End 0-3 Aston Villa | Emirates FA Cup Quarter Final |
| 39 | Wed 2 Apr | 43-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-3 Aston Villa | Premier League |
| 40 | Sat 5 Apr | 42-1 v Nottingham ForestAston Villa 2-1 Nottingham Forest | Premier League |
| 41 | Wed 9 Apr | 41-3 v Paris St GermainParis St Germain 3-1 Aston Villa | UEFA Champions League Quarter Final |
| 42 | Sat 12 Apr | 43-0 v SouthamptonSouthampton 0-3 Aston Villa | Premier League |
| 43 | Tue 15 Apr | 43-2 v Paris St GermainAston Villa 3-2 Paris St Germain | UEFA Champions League Quarter Final |
| 44 | Sat 19 Apr | 44-1 v Newcastle UnitedAston Villa 4-1 Newcastle United | Premier League |
| 45 | Tue 22 Apr | 41-2 v Manchester CityManchester City 2-1 Aston Villa | Premier League |
| 46 | Sat 26 Apr | 40-3 v Crystal PalaceCrystal Palace 3-0 Aston Villa | Emirates FA Cup Semi Final |
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