| 1 | Sun 29 Aug 2021 | 35-0 v VitesseAjax 5-0 Vitesse | Dutch Eredivisie |
| 2 | Wed 15 Sep 2021 | 35-1 v Sporting LisbonSporting Lisbon 1-5 Ajax | UEFA Champions League Group C |
| 3 | Sat 16 Oct 2021 | 32-0 v sc Heerenveensc Heerenveen 0-2 Ajax | Dutch Eredivisie |
| 4 | Sun 24 Oct 2021 | 35-0 v PSV EindhovenAjax 5-0 PSV Eindhoven | Dutch Eredivisie |
| 5 | Sat 30 Oct 2021 | 30-0 v Heracles AlmeloHeracles Almelo 0-0 Ajax | Dutch Eredivisie |
| 6 | Sun 7 Nov 2021 | 30-0 v Go Ahead EaglesAjax 0-0 Go Ahead Eagles | Dutch Eredivisie |
| 7 | Sun 21 Nov 2021 | 35-0 v RKC WaalwijkRKC Waalwijk 0-5 Ajax | Dutch Eredivisie |
| 8 | Wed 24 Nov 2021 | 32-1 v BeşiktaşBeşiktaş 1-2 Ajax | UEFA Champions League Group C |
| 9 | Thu 2 Dec 2021 | 35-0 v Willem IIAjax 5-0 Willem II | Dutch Eredivisie |
| 10 | Tue 7 Dec 2021 | 3 4-2 v Sporting LisbonAjax 4-2 Sporting Lisbon | UEFA Champions League Group C |
| 11 | Sun 12 Dec 2021 | 31-2 v AZ AlkmaarAjax 1-2 AZ Alkmaar | Dutch Eredivisie |
| 12 | Sun 19 Dec 2021 | 32-0 v FeyenoordFeyenoord 0-2 Ajax | Dutch Eredivisie |
| 13 | Wed 22 Dec 2021 | 35-0 v Fortuna SittardAjax 5-0 Fortuna Sittard | Dutch Eredivisie |
| 14 | Sun 16 Jan 2022 | 33-0 v FC UtrechtFC Utrecht 0-3 Ajax | Dutch Eredivisie |
| 15 | Sun 6 Feb 2022 | 33-0 v Heracles AlmeloAjax 3-0 Heracles Almelo | Dutch Eredivisie |
| 16 | Sat 19 Feb 2022 | 31-0 v Willem IIWillem II 0-1 Ajax | Dutch Eredivisie |
| 17 | Sun 27 Feb 2022 | 31-2 v Go Ahead EaglesGo Ahead Eagles 2-1 Ajax | Dutch Eredivisie |
| 18 | Sun 6 Mar 2022 | 33-2 v RKC WaalwijkAjax 3-2 RKC Waalwijk | Dutch Eredivisie |
| 19 | Sun 20 Mar 2022 | 33-2 v FeyenoordAjax 3-2 Feyenoord | Dutch Eredivisie |
| 20 | Sat 2 Apr 2022 | 33-1 v FC GroningenFC Groningen 1-3 Ajax | Dutch Eredivisie |
| 21 | Sat 9 Apr 2022 | 32-1 v Sparta RotterdamAjax 2-1 Sparta Rotterdam | Dutch Eredivisie |
| 22 | Sat 23 Apr 2022 | 31-0 v NEC NijmegenNEC Nijmegen 0-1 Ajax | Dutch Eredivisie |
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