| 1 | Sat 24 Aug | 33-2 v Holstein Kiel1899 Hoffenheim 3-2 Holstein Kiel | German Bundesliga |
| 2 | Sat 31 Aug | 31-3 v Eintracht FrankfurtEintracht Frankfurt 3-1 1899 Hoffenheim | German Bundesliga |
| 3 | Sat 14 Sep | 31-4 v Bayer 04 Leverkusen1899 Hoffenheim 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Sat 21 Sep | 3 1-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 1899 Hoffenheim | German Bundesliga |
| 5 | Wed 25 Sep | 31-1 v FC MidtjyllandFC Midtjylland 1-1 1899 Hoffenheim | UEFA Europa League Matchday 1 |
| 6 | Sun 29 Sep | 33-4 v Werder Bremen1899 Hoffenheim 3-4 Werder Bremen | German Bundesliga |
| 7 | Thu 3 Oct | 32-0 v Dynamo Kiev1899 Hoffenheim 2-0 Dynamo Kiev | UEFA Europa League Matchday 2 |
| 8 | Sun 27 Oct | 30-0 v 1 FC Heidenheim1 FC Heidenheim 0-0 1899 Hoffenheim | German Bundesliga |
| 9 | Sat 2 Nov | 30-2 v FC St Pauli1899 Hoffenheim 0-2 FC St Pauli | German Bundesliga |
| 10 | Thu 7 Nov | 32-2 v Lyon1899 Hoffenheim 2-2 Lyon | UEFA Europa League Matchday 4 |
| 11 | Sun 10 Nov | 3 0-0 v FC AugsburgFC Augsburg 0-0 1899 Hoffenheim | German Bundesliga |
| 12 | Sat 23 Nov | 3 4-3 v RB Leipzig1899 Hoffenheim 4-3 RB Leipzig | German Bundesliga |
| 13 | Sun 1 Dec | 3 0-2 v Mainz 05Mainz 05 2-0 1899 Hoffenheim | German Bundesliga |
| 14 | Thu 12 Dec | 30-0 v Steaua Bucharest1899 Hoffenheim 0-0 Steaua Bucharest | UEFA Europa League Matchday 6 |
| 15 | Sat 11 Jan | 30-1 v VfL Wolfsburg1899 Hoffenheim 0-1 VfL Wolfsburg | German Bundesliga |
| 16 | Wed 15 Jan | 3 0-5 v Bayern MunichBayern Munich 5-0 1899 Hoffenheim | German Bundesliga |
| 17 | Thu 23 Jan | 32-3 v Tottenham Hotspur1899 Hoffenheim 2-3 Tottenham Hotspur | UEFA Europa League Matchday 7 |
| 18 | Sun 26 Jan | 32-2 v Eintracht Frankfurt1899 Hoffenheim 2-2 Eintracht Frankfurt | German Bundesliga |
| 19 | Sat 8 Feb | 30-4 v 1 FC Union Berlin1899 Hoffenheim 0-4 1 FC Union Berlin | German Bundesliga |
| 20 | Sun 16 Feb | 33-1 v Werder BremenWerder Bremen 1-3 1899 Hoffenheim | German Bundesliga |
| 21 | Sat 1 Mar | 31-0 v VfL BochumVfL Bochum 0-1 1899 Hoffenheim | German Bundesliga |
| 22 | Sun 9 Mar | 31-1 v 1 FC Heidenheim1899 Hoffenheim 1-1 1 FC Heidenheim | German Bundesliga |
| 23 | Fri 14 Mar | 30-1 v FC St PauliFC St Pauli 1-0 1899 Hoffenheim | German Bundesliga |
| 24 | Sat 29 Mar | 31-1 v FC Augsburg1899 Hoffenheim 1-1 FC Augsburg | German Bundesliga |
| 25 | Sat 19 Apr | 32-3 v SC FreiburgSC Freiburg 3-2 1899 Hoffenheim | German Bundesliga |
| 26 | Sat 26 Apr | 3 2-3 v Borussia Dortmund1899 Hoffenheim 2-3 Borussia Dortmund | German Bundesliga |
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