| 1 | Sat 31 Aug | 261-3 v Eintracht FrankfurtEintracht Frankfurt 3-1 1899 Hoffenheim | German Bundesliga |
| 2 | Sat 21 Sep | 261-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 1899 Hoffenheim | German Bundesliga |
| 3 | Wed 25 Sep | 261-1 v FC MidtjyllandFC Midtjylland 1-1 1899 Hoffenheim | UEFA Europa League Matchday 1 |
| 4 | Sun 6 Oct | 261-1 v VfB StuttgartVfB Stuttgart 1-1 1899 Hoffenheim | German Bundesliga |
| 5 | Sat 19 Oct | 263-1 v VfL Bochum1899 Hoffenheim 3-1 VfL Bochum | German Bundesliga |
| 6 | Thu 24 Oct | 260-2 v FC PortoFC Porto 2-0 1899 Hoffenheim | UEFA Europa League Matchday 3 |
| 7 | Sat 2 Nov | 260-2 v FC St Pauli1899 Hoffenheim 0-2 FC St Pauli | German Bundesliga |
| 8 | Thu 7 Nov | 262-2 v Lyon1899 Hoffenheim 2-2 Lyon | UEFA Europa League Matchday 4 |
| 9 | Sun 10 Nov | 260-0 v FC AugsburgFC Augsburg 0-0 1899 Hoffenheim | German Bundesliga |
| 10 | Sat 23 Nov | 264-3 v RB Leipzig1899 Hoffenheim 4-3 RB Leipzig | German Bundesliga |
| 11 | Thu 28 Nov | 260-3 v Sporting BragaSporting Braga 3-0 1899 Hoffenheim | UEFA Europa League Matchday 5 |
| 12 | Sun 1 Dec | 260-2 v Mainz 05Mainz 05 2-0 1899 Hoffenheim | German Bundesliga |
| 13 | Thu 12 Dec | 260-0 v Steaua Bucharest1899 Hoffenheim 0-0 Steaua Bucharest | UEFA Europa League Matchday 6 |
| 14 | Sun 15 Dec | 261-1 v Borussia DortmundBorussia Dortmund 1-1 1899 Hoffenheim | German Bundesliga |
| 15 | Sat 21 Dec | 261-2 v Borussia Mönchengladbach1899 Hoffenheim 1-2 Borussia Mönchengladbach | German Bundesliga |
| 16 | Wed 15 Jan | 260-5 v Bayern MunichBayern Munich 5-0 1899 Hoffenheim | German Bundesliga |
| 17 | Sun 23 Feb | 261-1 v VfB Stuttgart1899 Hoffenheim 1-1 VfB Stuttgart | German Bundesliga |
| 18 | Sat 1 Mar | 261-0 v VfL BochumVfL Bochum 0-1 1899 Hoffenheim | German Bundesliga |
| 19 | Sun 9 Mar | 261-1 v 1 FC Heidenheim1899 Hoffenheim 1-1 1 FC Heidenheim | German Bundesliga |
| 20 | Fri 14 Mar | 260-1 v FC St PauliFC St Pauli 1-0 1899 Hoffenheim | German Bundesliga |
| 21 | Sat 29 Mar | 261-1 v FC Augsburg1899 Hoffenheim 1-1 FC Augsburg | German Bundesliga |
| 22 | Sat 5 Apr | 261-3 v RB LeipzigRB Leipzig 3-1 1899 Hoffenheim | German Bundesliga |
| 23 | Sat 12 Apr | 262-0 v Mainz 051899 Hoffenheim 2-0 Mainz 05 | German Bundesliga |
| 24 | Sat 19 Apr | 262-3 v SC FreiburgSC Freiburg 3-2 1899 Hoffenheim | German Bundesliga |
| 25 | Sat 26 Apr | 262-3 v Borussia Dortmund1899 Hoffenheim 2-3 Borussia Dortmund | German Bundesliga |
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