| 1 | Sat 24 Aug | 83-2 v Holstein Kiel1899 Hoffenheim 3-2 Holstein Kiel | German Bundesliga |
| 2 | Sat 31 Aug | 81-3 v Eintracht FrankfurtEintracht Frankfurt 3-1 1899 Hoffenheim | German Bundesliga |
| 3 | Sat 14 Sep | 8 1-4 v Bayer 04 Leverkusen1899 Hoffenheim 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Thu 28 Nov | 80-3 v Sporting BragaSporting Braga 3-0 1899 Hoffenheim | UEFA Europa League Matchday 5 |
| 5 | Sun 1 Dec | 80-2 v Mainz 05Mainz 05 2-0 1899 Hoffenheim | German Bundesliga |
| 6 | Sun 8 Dec | 8 1-1 v SC Freiburg1899 Hoffenheim 1-1 SC Freiburg | German Bundesliga |
| 7 | Thu 12 Dec | 8 0-0 v Steaua Bucharest1899 Hoffenheim 0-0 Steaua Bucharest | UEFA Europa League Matchday 6 |
| 8 | Sun 15 Dec | 8 1-1 v Borussia DortmundBorussia Dortmund 1-1 1899 Hoffenheim | German Bundesliga |
| 9 | Sat 21 Dec | 81-2 v Borussia Mönchengladbach1899 Hoffenheim 1-2 Borussia Mönchengladbach | German Bundesliga |
| 10 | Sat 11 Jan | 80-1 v VfL Wolfsburg1899 Hoffenheim 0-1 VfL Wolfsburg | German Bundesliga |
| 11 | Wed 15 Jan | 80-5 v Bayern MunichBayern Munich 5-0 1899 Hoffenheim | German Bundesliga |
| 12 | Sun 26 Jan | 82-2 v Eintracht Frankfurt1899 Hoffenheim 2-2 Eintracht Frankfurt | German Bundesliga |
| 13 | Thu 30 Jan | 8 4-3 v RSC AnderlechtRSC Anderlecht 3-4 1899 Hoffenheim | UEFA Europa League Matchday 8 |
| 14 | Sun 2 Feb | 8 1-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-1 1899 Hoffenheim | German Bundesliga |
| 15 | Sat 8 Feb | 8 0-4 v 1 FC Union Berlin1899 Hoffenheim 0-4 1 FC Union Berlin | German Bundesliga |
| 16 | Sun 16 Feb | 83-1 v Werder BremenWerder Bremen 1-3 1899 Hoffenheim | German Bundesliga |
| 17 | Sun 9 Mar | 81-1 v 1 FC Heidenheim1899 Hoffenheim 1-1 1 FC Heidenheim | German Bundesliga |
| 18 | Sat 29 Mar | 81-1 v FC Augsburg1899 Hoffenheim 1-1 FC Augsburg | German Bundesliga |
| 19 | Sat 12 Apr | 82-0 v Mainz 051899 Hoffenheim 2-0 Mainz 05 | German Bundesliga |
| 20 | Sat 19 Apr | 82-3 v SC FreiburgSC Freiburg 3-2 1899 Hoffenheim | German Bundesliga |
| 21 | Sat 26 Apr | 82-3 v Borussia Dortmund1899 Hoffenheim 2-3 Borussia Dortmund | German Bundesliga |
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