| 1 | Sun 6 Oct | 35 1-1 v VfB StuttgartVfB Stuttgart 1-1 1899 Hoffenheim | German Bundesliga |
| 2 | Sat 19 Oct | 353-1 v VfL Bochum1899 Hoffenheim 3-1 VfL Bochum | German Bundesliga |
| 3 | Thu 24 Oct | 350-2 v FC PortoFC Porto 2-0 1899 Hoffenheim | UEFA Europa League Matchday 3 |
| 4 | Sun 27 Oct | 350-0 v 1 FC Heidenheim1 FC Heidenheim 0-0 1899 Hoffenheim | German Bundesliga |
| 5 | Sat 2 Nov | 350-2 v FC St Pauli1899 Hoffenheim 0-2 FC St Pauli | German Bundesliga |
| 6 | Thu 7 Nov | 35 2-2 v Lyon1899 Hoffenheim 2-2 Lyon | UEFA Europa League Matchday 4 |
| 7 | Sun 10 Nov | 350-0 v FC AugsburgFC Augsburg 0-0 1899 Hoffenheim | German Bundesliga |
| 8 | Sat 23 Nov | 354-3 v RB Leipzig1899 Hoffenheim 4-3 RB Leipzig | German Bundesliga |
| 9 | Thu 28 Nov | 350-3 v Sporting BragaSporting Braga 3-0 1899 Hoffenheim | UEFA Europa League Matchday 5 |
| 10 | Sun 8 Dec | 351-1 v SC Freiburg1899 Hoffenheim 1-1 SC Freiburg | German Bundesliga |
| 11 | Thu 12 Dec | 35 0-0 v Steaua Bucharest1899 Hoffenheim 0-0 Steaua Bucharest | UEFA Europa League Matchday 6 |
| 12 | Sun 15 Dec | 351-1 v Borussia DortmundBorussia Dortmund 1-1 1899 Hoffenheim | German Bundesliga |
| 13 | Sat 11 Jan | 350-1 v VfL Wolfsburg1899 Hoffenheim 0-1 VfL Wolfsburg | German Bundesliga |
| 14 | Wed 15 Jan | 350-5 v Bayern MunichBayern Munich 5-0 1899 Hoffenheim | German Bundesliga |
| 15 | Sat 18 Jan | 35 3-1 v Holstein KielHolstein Kiel 1-3 1899 Hoffenheim | German Bundesliga |
| 16 | Thu 23 Jan | 352-3 v Tottenham Hotspur1899 Hoffenheim 2-3 Tottenham Hotspur | UEFA Europa League Matchday 7 |
| 17 | Sun 26 Jan | 35 2-2 v Eintracht Frankfurt1899 Hoffenheim 2-2 Eintracht Frankfurt | German Bundesliga |
| 18 | Thu 30 Jan | 354-3 v RSC AnderlechtRSC Anderlecht 3-4 1899 Hoffenheim | UEFA Europa League Matchday 8 |
| 19 | Sun 2 Feb | 351-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-1 1899 Hoffenheim | German Bundesliga |
| 20 | Sat 8 Feb | 350-4 v 1 FC Union Berlin1899 Hoffenheim 0-4 1 FC Union Berlin | German Bundesliga |
| 21 | Sun 16 Feb | 35 3-1 v Werder BremenWerder Bremen 1-3 1899 Hoffenheim | German Bundesliga |
| 22 | Sun 23 Feb | 351-1 v VfB Stuttgart1899 Hoffenheim 1-1 VfB Stuttgart | German Bundesliga |
| 23 | Sat 1 Mar | 351-0 v VfL BochumVfL Bochum 0-1 1899 Hoffenheim | German Bundesliga |
| 24 | Sun 9 Mar | 35 1-1 v 1 FC Heidenheim1899 Hoffenheim 1-1 1 FC Heidenheim | German Bundesliga |
| 25 | Sat 29 Mar | 351-1 v FC Augsburg1899 Hoffenheim 1-1 FC Augsburg | German Bundesliga |
| 26 | Sat 5 Apr | 35 1-3 v RB LeipzigRB Leipzig 3-1 1899 Hoffenheim | German Bundesliga |
| 27 | Sat 12 Apr | 35 2-0 v Mainz 051899 Hoffenheim 2-0 Mainz 05 | German Bundesliga |
| 28 | Sat 19 Apr | 352-3 v SC FreiburgSC Freiburg 3-2 1899 Hoffenheim | German Bundesliga |
| 29 | Sat 26 Apr | 35 2-3 v Borussia Dortmund1899 Hoffenheim 2-3 Borussia Dortmund | German Bundesliga |
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