| 1 | Sat 24 Aug | 163-2 v Holstein Kiel1899 Hoffenheim 3-2 Holstein Kiel | German Bundesliga |
| 2 | Sat 31 Aug | 161-3 v Eintracht FrankfurtEintracht Frankfurt 3-1 1899 Hoffenheim | German Bundesliga |
| 3 | Sat 14 Sep | 161-4 v Bayer 04 Leverkusen1899 Hoffenheim 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Sat 21 Sep | 161-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 1899 Hoffenheim | German Bundesliga |
| 5 | Sun 29 Sep | 16 3-4 v Werder Bremen1899 Hoffenheim 3-4 Werder Bremen | German Bundesliga |
| 6 | Thu 3 Oct | 162-0 v Dynamo Kiev1899 Hoffenheim 2-0 Dynamo Kiev | UEFA Europa League Matchday 2 |
| 7 | Sun 6 Oct | 161-1 v VfB StuttgartVfB Stuttgart 1-1 1899 Hoffenheim | German Bundesliga |
| 8 | Sat 19 Oct | 163-1 v VfL Bochum1899 Hoffenheim 3-1 VfL Bochum | German Bundesliga |
| 9 | Thu 24 Oct | 160-2 v FC PortoFC Porto 2-0 1899 Hoffenheim | UEFA Europa League Matchday 3 |
| 10 | Sun 27 Oct | 16 0-0 v 1 FC Heidenheim1 FC Heidenheim 0-0 1899 Hoffenheim | German Bundesliga |
| 11 | Sat 2 Nov | 160-2 v FC St Pauli1899 Hoffenheim 0-2 FC St Pauli | German Bundesliga |
| 12 | Thu 7 Nov | 16 2-2 v Lyon1899 Hoffenheim 2-2 Lyon | UEFA Europa League Matchday 4 |
| 13 | Sun 10 Nov | 160-0 v FC AugsburgFC Augsburg 0-0 1899 Hoffenheim | German Bundesliga |
| 14 | Sat 23 Nov | 164-3 v RB Leipzig1899 Hoffenheim 4-3 RB Leipzig | German Bundesliga |
| 15 | Thu 28 Nov | 160-3 v Sporting BragaSporting Braga 3-0 1899 Hoffenheim | UEFA Europa League Matchday 5 |
| 16 | Sun 1 Dec | 16 0-2 v Mainz 05Mainz 05 2-0 1899 Hoffenheim | German Bundesliga |
| 17 | Sun 8 Dec | 161-1 v SC Freiburg1899 Hoffenheim 1-1 SC Freiburg | German Bundesliga |
| 18 | Thu 12 Dec | 160-0 v Steaua Bucharest1899 Hoffenheim 0-0 Steaua Bucharest | UEFA Europa League Matchday 6 |
| 19 | Sun 15 Dec | 161-1 v Borussia DortmundBorussia Dortmund 1-1 1899 Hoffenheim | German Bundesliga |
| 20 | Sat 21 Dec | 161-2 v Borussia Mönchengladbach1899 Hoffenheim 1-2 Borussia Mönchengladbach | German Bundesliga |
| 21 | Sat 11 Jan | 160-1 v VfL Wolfsburg1899 Hoffenheim 0-1 VfL Wolfsburg | German Bundesliga |
| 22 | Sat 18 Jan | 163-1 v Holstein KielHolstein Kiel 1-3 1899 Hoffenheim | German Bundesliga |
| 23 | Thu 23 Jan | 162-3 v Tottenham Hotspur1899 Hoffenheim 2-3 Tottenham Hotspur | UEFA Europa League Matchday 7 |
| 24 | Sun 26 Jan | 16 2-2 v Eintracht Frankfurt1899 Hoffenheim 2-2 Eintracht Frankfurt | German Bundesliga |
| 25 | Sun 16 Feb | 163-1 v Werder BremenWerder Bremen 1-3 1899 Hoffenheim | German Bundesliga |
| 26 | Sun 23 Feb | 161-1 v VfB Stuttgart1899 Hoffenheim 1-1 VfB Stuttgart | German Bundesliga |
| 27 | Sat 1 Mar | 16 1-0 v VfL BochumVfL Bochum 0-1 1899 Hoffenheim | German Bundesliga |
| 28 | Fri 14 Mar | 16 0-1 v FC St PauliFC St Pauli 1-0 1899 Hoffenheim | German Bundesliga |
| 29 | Sat 29 Mar | 161-1 v FC Augsburg1899 Hoffenheim 1-1 FC Augsburg | German Bundesliga |
| 30 | Sat 5 Apr | 161-3 v RB LeipzigRB Leipzig 3-1 1899 Hoffenheim | German Bundesliga |
| 31 | Sat 12 Apr | 162-0 v Mainz 051899 Hoffenheim 2-0 Mainz 05 | German Bundesliga |
| 32 | Sat 19 Apr | 162-3 v SC FreiburgSC Freiburg 3-2 1899 Hoffenheim | German Bundesliga |
| 33 | Sat 26 Apr | 16 2-3 v Borussia Dortmund1899 Hoffenheim 2-3 Borussia Dortmund | German Bundesliga |
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