| 1 | Sat 6 Aug 2022 | 22 1-3 v Borussia MönchengladbachBorussia Mönchengladbach 3-1 1899 Hoffenheim | German Bundesliga |
| 2 | Sat 13 Aug 2022 | 223-2 v VfL Bochum1899 Hoffenheim 3-2 VfL Bochum | German Bundesliga |
| 3 | Sat 20 Aug 2022 | 223-0 v Bayer 04 LeverkusenBayer 04 Leverkusen 0-3 1899 Hoffenheim | German Bundesliga |
| 4 | Sat 27 Aug 2022 | 221-0 v FC Augsburg1899 Hoffenheim 1-0 FC Augsburg | German Bundesliga |
| 5 | Fri 2 Sep 2022 | 22 0-1 v Borussia DortmundBorussia Dortmund 1-0 1899 Hoffenheim | German Bundesliga |
| 6 | Sat 10 Sep 2022 | 22 4-1 v Mainz 051899 Hoffenheim 4-1 Mainz 05 | German Bundesliga |
| 7 | Sun 18 Sep 2022 | 220-0 v SC Freiburg1899 Hoffenheim 0-0 SC Freiburg | German Bundesliga |
| 8 | Sun 2 Oct 2022 | 221-1 v Hertha BerlinHertha Berlin 1-1 1899 Hoffenheim | German Bundesliga |
| 9 | Fri 7 Oct 2022 | 22 1-2 v Werder Bremen1899 Hoffenheim 1-2 Werder Bremen | German Bundesliga |
| 10 | Fri 14 Oct 2022 | 22 3-0 v FC Schalke 04FC Schalke 04 0-3 1899 Hoffenheim | German Bundesliga |
| 11 | Sun 30 Oct 2022 | 221-1 v 1 FC Köln1 FC Köln 1-1 1899 Hoffenheim | German Bundesliga |
| 12 | Sat 5 Nov 2022 | 221-3 v RB Leipzig1899 Hoffenheim 1-3 RB Leipzig | German Bundesliga |
| 13 | Wed 9 Nov 2022 | 22 2-4 v Eintracht FrankfurtEintracht Frankfurt 4-2 1899 Hoffenheim | German Bundesliga |
| 14 | Sat 12 Nov 2022 | 221-2 v VfL Wolfsburg1899 Hoffenheim 1-2 VfL Wolfsburg | German Bundesliga |
| 15 | Tue 24 Jan 2023 | 222-2 v VfB Stuttgart1899 Hoffenheim 2-2 VfB Stuttgart | German Bundesliga |
| 16 | Fri 17 Feb 2023 | 220-1 v FC AugsburgFC Augsburg 1-0 1899 Hoffenheim | German Bundesliga |
| 17 | Sat 25 Feb 2023 | 22 0-1 v Borussia Dortmund1899 Hoffenheim 0-1 Borussia Dortmund | German Bundesliga |
| 18 | Sat 4 Mar 2023 | 22 0-1 v Mainz 05Mainz 05 1-0 1899 Hoffenheim | German Bundesliga |
| 19 | Sat 18 Mar 2023 | 223-1 v Hertha Berlin1899 Hoffenheim 3-1 Hertha Berlin | German Bundesliga |
| 20 | Sun 2 Apr 2023 | 222-1 v Werder BremenWerder Bremen 1-2 1899 Hoffenheim | German Bundesliga |
| 21 | Sun 9 Apr 2023 | 222-0 v FC Schalke 041899 Hoffenheim 2-0 FC Schalke 04 | German Bundesliga |
| 22 | Sat 22 Apr 2023 | 221-3 v 1 FC Köln1899 Hoffenheim 1-3 1 FC Köln | German Bundesliga |
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