| 1 | Sat 14 Aug 2021 | 234-0 v FC AugsburgFC Augsburg 0-4 1899 Hoffenheim | German Bundesliga |
| 2 | Sun 22 Aug 2021 | 232-2 v 1. FC Union Berlin1899 Hoffenheim 2-2 1. FC Union Berlin | German Bundesliga |
| 3 | Fri 27 Aug 2021 | 232-3 v Borussia DortmundBorussia Dortmund 3-2 1899 Hoffenheim | German Bundesliga |
| 4 | Sat 18 Sep 2021 | 230-0 v Arminia BielefeldArminia Bielefeld 0-0 1899 Hoffenheim | German Bundesliga |
| 5 | Sat 25 Sep 2021 | 233-1 v VfL Wolfsburg1899 Hoffenheim 3-1 VfL Wolfsburg | German Bundesliga |
| 6 | Sat 2 Oct 2021 | 231-3 v VfB StuttgartVfB Stuttgart 3-1 1899 Hoffenheim | German Bundesliga |
| 7 | Sat 23 Oct 2021 | 230-4 v Bayern MunichBayern Munich 4-0 1899 Hoffenheim | German Bundesliga |
| 8 | Sat 20 Nov 2021 | 232-0 v RB Leipzig1899 Hoffenheim 2-0 RB Leipzig | German Bundesliga |
| 9 | Sat 27 Nov 2021 | 236-3 v Greuther FürthGreuther Fürth 3-6 1899 Hoffenheim | German Bundesliga |
| 10 | Sat 4 Dec 2021 | 233-2 v Eintracht Frankfurt1899 Hoffenheim 3-2 Eintracht Frankfurt | German Bundesliga |
| 11 | Sat 11 Dec 2021 | 232-1 v SC FreiburgSC Freiburg 1-2 1899 Hoffenheim | German Bundesliga |
| 12 | Wed 15 Dec 2021 | 232-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-2 1899 Hoffenheim | German Bundesliga |
| 13 | Sat 8 Jan 2022 | 233-1 v FC Augsburg1899 Hoffenheim 3-1 FC Augsburg | German Bundesliga |
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