| 1 | Sat 19 Sep 2020 | 83-2 v 1. FC Köln1. FC Köln 2-3 1899 Hoffenheim | German Bundesliga |
| 2 | Sun 27 Sep 2020 | 8 4-1 v Bayern Munich1899 Hoffenheim 4-1 Bayern Munich | German Bundesliga |
| 3 | Sat 3 Oct 2020 | 8 1-2 v Eintracht FrankfurtEintracht Frankfurt 2-1 1899 Hoffenheim | German Bundesliga |
| 4 | Sat 17 Oct 2020 | 80-1 v Borussia Dortmund1899 Hoffenheim 0-1 Borussia Dortmund | German Bundesliga |
| 5 | Thu 22 Oct 2020 | 82-0 v Red Star Belgrade1899 Hoffenheim 2-0 Red Star Belgrade | Europa League Group L |
| 6 | Sun 25 Oct 2020 | 81-1 v Werder BremenWerder Bremen 1-1 1899 Hoffenheim | German Bundesliga |
| 7 | Mon 2 Nov 2020 | 81-3 v 1. FC Union Berlin1899 Hoffenheim 1-3 1. FC Union Berlin | German Bundesliga |
| 8 | Sat 21 Nov 2020 | 8 3-3 v VfB Stuttgart1899 Hoffenheim 3-3 VfB Stuttgart | German Bundesliga |
| 9 | Thu 26 Nov 2020 | 82-0 v Slovan LiberecSlovan Liberec 0-2 1899 Hoffenheim | Europa League Group L |
| 10 | Sun 29 Nov 2020 | 8 1-1 v Mainz 05Mainz 05 1-1 1899 Hoffenheim | German Bundesliga |
| 11 | Thu 3 Dec 2020 | 80-0 v Red Star BelgradeRed Star Belgrade 0-0 1899 Hoffenheim | Europa League Group L |
| 12 | Thu 10 Dec 2020 | 84-1 v KAA Gent1899 Hoffenheim 4-1 KAA Gent | Europa League Group L |
| 13 | Sat 19 Dec 2020 | 8 2-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-2 1899 Hoffenheim | German Bundesliga |
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